Treatment of the West syndrome with high-dose pyridoxal phosphate

Y. Ohtsuka, M. Matsuda, T. Ogino, Katsuhiro Kobayashi, S. Ohtahara

Research output: Contribution to journalArticle

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Abstract

Fifteen (12.7%) among 118 cases of the West syndrome were effectively treated by high-dose pyridoxal phosphate (PAL-P). 1) Clinical seizures were completely suppressed in 12 cases with PAL-P alone, and in 3 cases by an addition of PAL-P to the previously poorly-effective regimen. At the follow-up, 12 cases have continued to be free from seizures, while two cases relapsed into the Lennox-Gastaut syndrome, and one died. 2) Electroencephalographically hypsarrhythmia disappeared by PAL-P in all 15 effective cases. 3) Effective daily dose of PAL-P was 30 to 400 mg. 4) Notably, PAL-P was effective even in the cases with obvious organic brain pathology, such as tuberous sclerosis, porencephaly, holoprosencephaly, postmeningitis, besides 5 idiopathic cases. 5) Efficacy of PAL-P was significantly higher in idiopathic cases than symptomatic cases; 35.7% vs 9.6%. 6) Response to PAL-P was not predictable by any laboratory data nor clinical features. 7) Prognosis of PAL-P responsive cases was favorable; as many as 6 cases developed normally among 14 cases followed-up. Treatment with a high-dose PAL-P should be tried in all cases of the West syndrome at first.

Original languageEnglish
Pages (from-to)418-421
Number of pages4
JournalBrain and Development
Volume9
Issue number4
Publication statusPublished - 1987

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Infantile Spasms
Pyridoxal Phosphate
Seizures
Holoprosencephaly
Tuberous Sclerosis
Pathology

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Ohtsuka, Y., Matsuda, M., Ogino, T., Kobayashi, K., & Ohtahara, S. (1987). Treatment of the West syndrome with high-dose pyridoxal phosphate. Brain and Development, 9(4), 418-421.

Treatment of the West syndrome with high-dose pyridoxal phosphate. / Ohtsuka, Y.; Matsuda, M.; Ogino, T.; Kobayashi, Katsuhiro; Ohtahara, S.

In: Brain and Development, Vol. 9, No. 4, 1987, p. 418-421.

Research output: Contribution to journalArticle

Ohtsuka, Y, Matsuda, M, Ogino, T, Kobayashi, K & Ohtahara, S 1987, 'Treatment of the West syndrome with high-dose pyridoxal phosphate', Brain and Development, vol. 9, no. 4, pp. 418-421.
Ohtsuka, Y. ; Matsuda, M. ; Ogino, T. ; Kobayashi, Katsuhiro ; Ohtahara, S. / Treatment of the West syndrome with high-dose pyridoxal phosphate. In: Brain and Development. 1987 ; Vol. 9, No. 4. pp. 418-421.
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