Treatment of refractory metastatic choriocarcinoma with tandem high- dose chemotherapy supported by peripheral blood stem cell transplantation: A case report

Rika Kawanishi, Akihiro Bessho, Hiroshi Ueoka, Masahiro Tabata, Katsuji Shinagawa, Kenichi Chikamori, Haruyuki Kawai, Naokatsu Horita, Mine Harada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Currently, 70% to 80% of patients with advanced germ cell tumors can be cured with cisplatin-based chemotherapy, followed by surgical resection of the residual tumor. The prognosis, however, is uniformly poor for patients who fail to respond to induction chemotherapy. In this report, we describe a patient with retroperitoneal choriocarcinoma and multiple lung metastases, who was refractory to cisplatin-based chemotherapy, but who achieved a durable marker-negative partial response after 2 cycles of high-dose chemotherapy, supported by autologous, peripheral blood stem cell transplantation. The patient is now alive and well, without recurrence, more than 24 months after this therapy.

Original languageEnglish
Pages (from-to)261-264
Number of pages4
JournalInternational Journal of Clinical Oncology
Volume3
Issue number4
DOIs
Publication statusPublished - 1998

Fingerprint

Peripheral Blood Stem Cell Transplantation
Choriocarcinoma
Drug Therapy
Cisplatin
Induction Chemotherapy
Germ Cell and Embryonal Neoplasms
Residual Neoplasm
Therapeutics
Neoplasm Metastasis
Recurrence
Lung

Keywords

  • Advanced choriocarcinoma
  • High-dose chemotherapy
  • Peripheral blood stem cell transplantation

ASJC Scopus subject areas

  • Oncology

Cite this

Treatment of refractory metastatic choriocarcinoma with tandem high- dose chemotherapy supported by peripheral blood stem cell transplantation : A case report. / Kawanishi, Rika; Bessho, Akihiro; Ueoka, Hiroshi; Tabata, Masahiro; Shinagawa, Katsuji; Chikamori, Kenichi; Kawai, Haruyuki; Horita, Naokatsu; Harada, Mine.

In: International Journal of Clinical Oncology, Vol. 3, No. 4, 1998, p. 261-264.

Research output: Contribution to journalArticle

Kawanishi, Rika ; Bessho, Akihiro ; Ueoka, Hiroshi ; Tabata, Masahiro ; Shinagawa, Katsuji ; Chikamori, Kenichi ; Kawai, Haruyuki ; Horita, Naokatsu ; Harada, Mine. / Treatment of refractory metastatic choriocarcinoma with tandem high- dose chemotherapy supported by peripheral blood stem cell transplantation : A case report. In: International Journal of Clinical Oncology. 1998 ; Vol. 3, No. 4. pp. 261-264.
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