Abstract
Currently, 70% to 80% of patients with advanced germ cell tumors can be cured with cisplatin-based chemotherapy, followed by surgical resection of the residual tumor. The prognosis, however, is uniformly poor for patients who fail to respond to induction chemotherapy. In this report, we describe a patient with retroperitoneal choriocarcinoma and multiple lung metastases, who was refractory to cisplatin-based chemotherapy, but who achieved a durable marker-negative partial response after 2 cycles of high-dose chemotherapy, supported by autologous, peripheral blood stem cell transplantation. The patient is now alive and well, without recurrence, more than 24 months after this therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 261-264 |
| Number of pages | 4 |
| Journal | International Journal of Clinical Oncology |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 13 1998 |
Keywords
- Advanced choriocarcinoma
- High-dose chemotherapy
- Peripheral blood stem cell transplantation
ASJC Scopus subject areas
- Surgery
- Hematology
- Oncology
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Cite this
Kawanishi, R., Bessho, A., Ueoka, H., Tabata, M., Shinagawa, K., Chikamori, K., Kawai, H., Horita, N., & Harada, M. (1998). Treatment of refractory metastatic choriocarcinoma with tandem high- dose chemotherapy supported by peripheral blood stem cell transplantation: A case report. International Journal of Clinical Oncology, 3(4), 261-264. https://doi.org/10.1007/BF02489844