TY - JOUR
T1 - Treatment of refractory metastatic choriocarcinoma with tandem high- dose chemotherapy supported by peripheral blood stem cell transplantation
T2 - A case report
AU - Kawanishi, Rika
AU - Bessho, Akihiro
AU - Ueoka, Hiroshi
AU - Tabata, Masahiro
AU - Shinagawa, Katsuji
AU - Chikamori, Kenichi
AU - Kawai, Haruyuki
AU - Horita, Naokatsu
AU - Harada, Mine
PY - 1998/10/13
Y1 - 1998/10/13
N2 - Currently, 70% to 80% of patients with advanced germ cell tumors can be cured with cisplatin-based chemotherapy, followed by surgical resection of the residual tumor. The prognosis, however, is uniformly poor for patients who fail to respond to induction chemotherapy. In this report, we describe a patient with retroperitoneal choriocarcinoma and multiple lung metastases, who was refractory to cisplatin-based chemotherapy, but who achieved a durable marker-negative partial response after 2 cycles of high-dose chemotherapy, supported by autologous, peripheral blood stem cell transplantation. The patient is now alive and well, without recurrence, more than 24 months after this therapy.
AB - Currently, 70% to 80% of patients with advanced germ cell tumors can be cured with cisplatin-based chemotherapy, followed by surgical resection of the residual tumor. The prognosis, however, is uniformly poor for patients who fail to respond to induction chemotherapy. In this report, we describe a patient with retroperitoneal choriocarcinoma and multiple lung metastases, who was refractory to cisplatin-based chemotherapy, but who achieved a durable marker-negative partial response after 2 cycles of high-dose chemotherapy, supported by autologous, peripheral blood stem cell transplantation. The patient is now alive and well, without recurrence, more than 24 months after this therapy.
KW - Advanced choriocarcinoma
KW - High-dose chemotherapy
KW - Peripheral blood stem cell transplantation
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U2 - 10.1007/BF02489844
DO - 10.1007/BF02489844
M3 - Article
AN - SCOPUS:0031706327
VL - 3
SP - 261
EP - 264
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
SN - 1341-9625
IS - 4
ER -