Treatment of premenstrual mood changes in a patient with schizophrenia using dienogest: A case report

Yasuhiko Kamada, Ai Sakamoto, Sayoko Kotani, Hisashi Masuyama

Research output: Contribution to journalArticle

Abstract

Dienogest is a fourth-generation progestin that is used for the treatment of endometriosis. We report a case of premenstrual mood changes in a patient with schizophrenia who was unresponsive to conventional treatment but successfully managed with dienogest. A 37-year-old Japanese woman with schizophrenia was referred to our hospital and diagnosed with premenstrual exacerbation of schizophrenia or coexisting premenstrual dysphoric disorder with schizophrenia. She had already taken maximal doses of selective serotonin reuptake inhibitors and combined oral contraceptives produced intolerable side effects. Gonadotropin-releasing hormone agonist treatment was effective but was not suitable for long-term use. Dienogest was initiated to treat pelvic endometriosis and produced subsequent improvements in mental status. The patient was able to return to work and did not indicate any adverse effects. This case suggests that dienogest may be useful for managing premenstrual mood changes in patients with schizophrenia, that it can be safely administered over long periods of time.

Original languageEnglish
Pages (from-to)797-800
Number of pages4
JournalJournal of Obstetrics and Gynaecology Research
Volume44
Issue number4
DOIs
Publication statusPublished - Apr 1 2018

Fingerprint

dienogest
Schizophrenia
Endometriosis
Contraceptives, Oral, Combined
Therapeutics
Return to Work
Serotonin Uptake Inhibitors
Progestins
Gonadotropin-Releasing Hormone

Keywords

  • dienogest
  • endometriosis
  • premenstrual dysphoric disorder
  • premenstrual exacerbation
  • progestin

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Treatment of premenstrual mood changes in a patient with schizophrenia using dienogest : A case report. / Kamada, Yasuhiko; Sakamoto, Ai; Kotani, Sayoko; Masuyama, Hisashi.

In: Journal of Obstetrics and Gynaecology Research, Vol. 44, No. 4, 01.04.2018, p. 797-800.

Research output: Contribution to journalArticle

@article{96ac6b98f27f44c49c0dc4e8ba1a2496,
title = "Treatment of premenstrual mood changes in a patient with schizophrenia using dienogest: A case report",
abstract = "Dienogest is a fourth-generation progestin that is used for the treatment of endometriosis. We report a case of premenstrual mood changes in a patient with schizophrenia who was unresponsive to conventional treatment but successfully managed with dienogest. A 37-year-old Japanese woman with schizophrenia was referred to our hospital and diagnosed with premenstrual exacerbation of schizophrenia or coexisting premenstrual dysphoric disorder with schizophrenia. She had already taken maximal doses of selective serotonin reuptake inhibitors and combined oral contraceptives produced intolerable side effects. Gonadotropin-releasing hormone agonist treatment was effective but was not suitable for long-term use. Dienogest was initiated to treat pelvic endometriosis and produced subsequent improvements in mental status. The patient was able to return to work and did not indicate any adverse effects. This case suggests that dienogest may be useful for managing premenstrual mood changes in patients with schizophrenia, that it can be safely administered over long periods of time.",
keywords = "dienogest, endometriosis, premenstrual dysphoric disorder, premenstrual exacerbation, progestin",
author = "Yasuhiko Kamada and Ai Sakamoto and Sayoko Kotani and Hisashi Masuyama",
year = "2018",
month = "4",
day = "1",
doi = "10.1111/jog.13578",
language = "English",
volume = "44",
pages = "797--800",
journal = "Journal of Obstetrics and Gynaecology Research",
issn = "1341-8076",
publisher = "Blackwell Publishing Asia",
number = "4",

}

TY - JOUR

T1 - Treatment of premenstrual mood changes in a patient with schizophrenia using dienogest

T2 - A case report

AU - Kamada, Yasuhiko

AU - Sakamoto, Ai

AU - Kotani, Sayoko

AU - Masuyama, Hisashi

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Dienogest is a fourth-generation progestin that is used for the treatment of endometriosis. We report a case of premenstrual mood changes in a patient with schizophrenia who was unresponsive to conventional treatment but successfully managed with dienogest. A 37-year-old Japanese woman with schizophrenia was referred to our hospital and diagnosed with premenstrual exacerbation of schizophrenia or coexisting premenstrual dysphoric disorder with schizophrenia. She had already taken maximal doses of selective serotonin reuptake inhibitors and combined oral contraceptives produced intolerable side effects. Gonadotropin-releasing hormone agonist treatment was effective but was not suitable for long-term use. Dienogest was initiated to treat pelvic endometriosis and produced subsequent improvements in mental status. The patient was able to return to work and did not indicate any adverse effects. This case suggests that dienogest may be useful for managing premenstrual mood changes in patients with schizophrenia, that it can be safely administered over long periods of time.

AB - Dienogest is a fourth-generation progestin that is used for the treatment of endometriosis. We report a case of premenstrual mood changes in a patient with schizophrenia who was unresponsive to conventional treatment but successfully managed with dienogest. A 37-year-old Japanese woman with schizophrenia was referred to our hospital and diagnosed with premenstrual exacerbation of schizophrenia or coexisting premenstrual dysphoric disorder with schizophrenia. She had already taken maximal doses of selective serotonin reuptake inhibitors and combined oral contraceptives produced intolerable side effects. Gonadotropin-releasing hormone agonist treatment was effective but was not suitable for long-term use. Dienogest was initiated to treat pelvic endometriosis and produced subsequent improvements in mental status. The patient was able to return to work and did not indicate any adverse effects. This case suggests that dienogest may be useful for managing premenstrual mood changes in patients with schizophrenia, that it can be safely administered over long periods of time.

KW - dienogest

KW - endometriosis

KW - premenstrual dysphoric disorder

KW - premenstrual exacerbation

KW - progestin

UR - http://www.scopus.com/inward/record.url?scp=85045114547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045114547&partnerID=8YFLogxK

U2 - 10.1111/jog.13578

DO - 10.1111/jog.13578

M3 - Article

C2 - 29359527

AN - SCOPUS:85045114547

VL - 44

SP - 797

EP - 800

JO - Journal of Obstetrics and Gynaecology Research

JF - Journal of Obstetrics and Gynaecology Research

SN - 1341-8076

IS - 4

ER -