[Treatment of hypertriglyceridemia with omega-3 fatty acids].

Research output: Contribution to journalReview article

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Abstract

Omega-3 fatty acids such as eicosapentaenoic acid(EPA) and docosahexaenoic acid(DHA) have important biologic functions, including effects on membranes, eicosanoid metabolism, and gene transcription. Studies indicate that the use of EPA and DHA lowered triglyceride levels, which is accomplished by decreasing the production of hepatic triglycerides and increasing the clearance of plasma triglycerides. Recent clinical studies showed that intake of omega-3 fatty acids reduced cardiovascular events. In addition, combination therapy with omega-3 fatty acids and a statin is a safe and effective way to improve lipid levels and cardiovascular prognosis beyond the benefits provided by statin therapy alone. Our focus is to review the potential mechanisms by which these fatty acids reduce cardiovascular disease risk.

Original languageEnglish
Pages (from-to)1650-1654
Number of pages5
JournalNihon rinsho. Japanese journal of clinical medicine
Volume71
Issue number9
Publication statusPublished - Sep 2013

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ASJC Scopus subject areas

  • Medicine(all)

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