Treatment of Ewing's sarcoma in the cooperative Ewing's sarcoma study group

Toshifumi Ozaki, Winfried Winkelmann, Normann Willich, Herbert Jürgens

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Multidisciplinary treatment approaches have greatly improved the prognosis of patients with Ewing's sarcoma. Four- or five-drug combination chemotherapy regimens are combined with radiation and/or surgery for local control. Currently, in the Cooperative Ewing's Sancoma Study (CESS) trials, approximately 60% of the protocol patients with Ewing's sarcoma show a relapse-free 10-year survival. For improvement of local control, preoperative radiotherapy and/or brachytherapy may be helpful. The early detection of blood and/or bone marrow contamination by molecular diagnosis can lead to a new clinical staging system. A myeloablative regimen consisting of simultaneous total body irradiation and chemotherapy may improve the prognosis of patients with disseminated disease.

Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalJournal of Orthopaedic Science
Volume2
Issue number3
DOIs
Publication statusPublished - Jan 1 1997

Keywords

  • Chemotherapy
  • Ewing's sarcoma
  • Prognosis
  • Radio-therapy
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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