Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders

Miki Inutsuka, Katsuhiro Kobayashi, Makio Oka, Junri Hattori, Yoko Ohtsuka

Research output: Contribution to journalArticle

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Abstract

To elucidate an effective therapeutic strategy for 'ESES syndrome', epilepsy with electrical status epilepticus during slow sleep (ESES) and its related epileptic disorders, we studied the effect of treatment on the EEG pattern of continuous spike-waves during slow wave sleep (CSWS) in 15 afflicted patients. Basically performed in the following order, the employed therapies included (1) high-dose valproate (VPA) therapy (serum level >100 μg/ml); (2) a combination therapy of VPA and ethosuximide (ESM); (3) short cycles of high-dose diazepam (oral or intrarectal DZP, 0.5-1 mg/kg per day for 6-7 days); and (4) intramuscular synthetic ACTH-Z therapy (0.01-0.04 mg/kg per day for 11-43 days). Regarding the initial EEG effect, a remission of CSWS was achieved by high-dose VPA therapy in 7 of 15 trials (47%), by the combination therapy of VPA and ESM in 3/7 trials (43%), by short cycles of high-dose DZP in 2/4 trials (50%), and by ACTH-Z therapy in 2/5 trials (40%). A permanent remission of ESES syndrome was achieved by high-dose VPA therapy and/or combination therapy of VPA and ESM in 10 patients (67%). The effects of short cycles of high-dose DZP and ACTH-Z therapy were at best temporary. Our strategy for the treatment of ESES syndrome is therefore considered valid.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalBrain and Development
Volume28
Issue number5
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Status Epilepticus
Epilepsy
Sleep
Valproic Acid
Ethosuximide
Therapeutics
Electroencephalography
Cosyntropin
Diazepam

Keywords

  • ACTH
  • CSWS
  • ESES
  • Ethosuximide
  • High-dose valproate
  • Short cycle of high-dose diazepam

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders. / Inutsuka, Miki; Kobayashi, Katsuhiro; Oka, Makio; Hattori, Junri; Ohtsuka, Yoko.

In: Brain and Development, Vol. 28, No. 5, 06.2006, p. 281-286.

Research output: Contribution to journalArticle

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