Treatment in Patients with Hypertrophic Obstructive Cardiomyopathy: A New Strategy used in our Hospital and the Results

Masashi Yoshida, Ichiro Inoue, Takuji Kawagoe, Masaharu Ishihara, Yuji Shimatani, Satoshi Kurisu, Kenji Nishioka, Takashi Umemura, Shuji Nakamura, Maoto Habara

Research output: Contribution to journalArticle

Abstract

Objective: In the treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM), the effects of drug therapy using negative inotropic drugs, percutaneous transluminal septal myocardial ablation (PTSMA), DDD pacemakers and surgical myectomy/myotomy are well recognized. In this study, we investigate a new treatment strategy used in our hospital for the last year. Methods: Eight patients diagnosed with HOCM by catheter examinations received a temporary DDD pacemaker, temporary septal branch occlusion, and a disopyramide intravenous infusion. The systolic pressure gradient of the left ventricular outflow tract was measured before and after the provocations, and then we decided which therapy was the best for each patient. Result: Two patients received PTSMA, one received a DDD pacemaker, and five received medical therapy. Three of the medical therapy patients gained a higher LVOTG, and for two of them their therapy was changed to PTSMA. Each of the LVOTGs were reduced to a theraputic level and good results were obtained. Finally, four patients received PTSMA, one received a DDD pacemaker, and three received medical therapy. Conclusion: There may be a difference between internal use and intravenous infusion in the effect of disopyramide. PTSMA was effective for these patients and considered to be an effective therapy for patients with HOCM.

Original languageEnglish
Pages (from-to)446-450
Number of pages5
JournalJapanese Journal of Interventional Cardiology
Volume18
Issue number5
Publication statusPublished - 2003
Externally publishedYes

Fingerprint

Hypertrophic Cardiomyopathy
Dichlorodiphenyldichloroethane
Disopyramide
Therapeutics
Intravenous Infusions
Catheters
Blood Pressure
Drug Therapy
Pharmaceutical Preparations

Keywords

  • DDD pacing
  • HOCM
  • Myocardial ablation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Treatment in Patients with Hypertrophic Obstructive Cardiomyopathy : A New Strategy used in our Hospital and the Results. / Yoshida, Masashi; Inoue, Ichiro; Kawagoe, Takuji; Ishihara, Masaharu; Shimatani, Yuji; Kurisu, Satoshi; Nishioka, Kenji; Umemura, Takashi; Nakamura, Shuji; Habara, Maoto.

In: Japanese Journal of Interventional Cardiology, Vol. 18, No. 5, 2003, p. 446-450.

Research output: Contribution to journalArticle

Yoshida, M, Inoue, I, Kawagoe, T, Ishihara, M, Shimatani, Y, Kurisu, S, Nishioka, K, Umemura, T, Nakamura, S & Habara, M 2003, 'Treatment in Patients with Hypertrophic Obstructive Cardiomyopathy: A New Strategy used in our Hospital and the Results', Japanese Journal of Interventional Cardiology, vol. 18, no. 5, pp. 446-450.
Yoshida, Masashi ; Inoue, Ichiro ; Kawagoe, Takuji ; Ishihara, Masaharu ; Shimatani, Yuji ; Kurisu, Satoshi ; Nishioka, Kenji ; Umemura, Takashi ; Nakamura, Shuji ; Habara, Maoto. / Treatment in Patients with Hypertrophic Obstructive Cardiomyopathy : A New Strategy used in our Hospital and the Results. In: Japanese Journal of Interventional Cardiology. 2003 ; Vol. 18, No. 5. pp. 446-450.
@article{2c7e3032460e4ad3a844ca0ffae1d1f4,
title = "Treatment in Patients with Hypertrophic Obstructive Cardiomyopathy: A New Strategy used in our Hospital and the Results",
abstract = "Objective: In the treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM), the effects of drug therapy using negative inotropic drugs, percutaneous transluminal septal myocardial ablation (PTSMA), DDD pacemakers and surgical myectomy/myotomy are well recognized. In this study, we investigate a new treatment strategy used in our hospital for the last year. Methods: Eight patients diagnosed with HOCM by catheter examinations received a temporary DDD pacemaker, temporary septal branch occlusion, and a disopyramide intravenous infusion. The systolic pressure gradient of the left ventricular outflow tract was measured before and after the provocations, and then we decided which therapy was the best for each patient. Result: Two patients received PTSMA, one received a DDD pacemaker, and five received medical therapy. Three of the medical therapy patients gained a higher LVOTG, and for two of them their therapy was changed to PTSMA. Each of the LVOTGs were reduced to a theraputic level and good results were obtained. Finally, four patients received PTSMA, one received a DDD pacemaker, and three received medical therapy. Conclusion: There may be a difference between internal use and intravenous infusion in the effect of disopyramide. PTSMA was effective for these patients and considered to be an effective therapy for patients with HOCM.",
keywords = "DDD pacing, HOCM, Myocardial ablation",
author = "Masashi Yoshida and Ichiro Inoue and Takuji Kawagoe and Masaharu Ishihara and Yuji Shimatani and Satoshi Kurisu and Kenji Nishioka and Takashi Umemura and Shuji Nakamura and Maoto Habara",
year = "2003",
language = "English",
volume = "18",
pages = "446--450",
journal = "Japanese Journal of Interventional Cardiology",
issn = "0914-8922",
publisher = "Japanese Society of Interventional Cardiology",
number = "5",

}

TY - JOUR

T1 - Treatment in Patients with Hypertrophic Obstructive Cardiomyopathy

T2 - A New Strategy used in our Hospital and the Results

AU - Yoshida, Masashi

AU - Inoue, Ichiro

AU - Kawagoe, Takuji

AU - Ishihara, Masaharu

AU - Shimatani, Yuji

AU - Kurisu, Satoshi

AU - Nishioka, Kenji

AU - Umemura, Takashi

AU - Nakamura, Shuji

AU - Habara, Maoto

PY - 2003

Y1 - 2003

N2 - Objective: In the treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM), the effects of drug therapy using negative inotropic drugs, percutaneous transluminal septal myocardial ablation (PTSMA), DDD pacemakers and surgical myectomy/myotomy are well recognized. In this study, we investigate a new treatment strategy used in our hospital for the last year. Methods: Eight patients diagnosed with HOCM by catheter examinations received a temporary DDD pacemaker, temporary septal branch occlusion, and a disopyramide intravenous infusion. The systolic pressure gradient of the left ventricular outflow tract was measured before and after the provocations, and then we decided which therapy was the best for each patient. Result: Two patients received PTSMA, one received a DDD pacemaker, and five received medical therapy. Three of the medical therapy patients gained a higher LVOTG, and for two of them their therapy was changed to PTSMA. Each of the LVOTGs were reduced to a theraputic level and good results were obtained. Finally, four patients received PTSMA, one received a DDD pacemaker, and three received medical therapy. Conclusion: There may be a difference between internal use and intravenous infusion in the effect of disopyramide. PTSMA was effective for these patients and considered to be an effective therapy for patients with HOCM.

AB - Objective: In the treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM), the effects of drug therapy using negative inotropic drugs, percutaneous transluminal septal myocardial ablation (PTSMA), DDD pacemakers and surgical myectomy/myotomy are well recognized. In this study, we investigate a new treatment strategy used in our hospital for the last year. Methods: Eight patients diagnosed with HOCM by catheter examinations received a temporary DDD pacemaker, temporary septal branch occlusion, and a disopyramide intravenous infusion. The systolic pressure gradient of the left ventricular outflow tract was measured before and after the provocations, and then we decided which therapy was the best for each patient. Result: Two patients received PTSMA, one received a DDD pacemaker, and five received medical therapy. Three of the medical therapy patients gained a higher LVOTG, and for two of them their therapy was changed to PTSMA. Each of the LVOTGs were reduced to a theraputic level and good results were obtained. Finally, four patients received PTSMA, one received a DDD pacemaker, and three received medical therapy. Conclusion: There may be a difference between internal use and intravenous infusion in the effect of disopyramide. PTSMA was effective for these patients and considered to be an effective therapy for patients with HOCM.

KW - DDD pacing

KW - HOCM

KW - Myocardial ablation

UR - http://www.scopus.com/inward/record.url?scp=0242642745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242642745&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0242642745

VL - 18

SP - 446

EP - 450

JO - Japanese Journal of Interventional Cardiology

JF - Japanese Journal of Interventional Cardiology

SN - 0914-8922

IS - 5

ER -