Abstract
Objective: In the treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM), the effects of drug therapy using negative inotropic drugs, percutaneous transluminal septal myocardial ablation (PTSMA), DDD pacemakers and surgical myectomy/myotomy are well recognized. In this study, we investigate a new treatment strategy used in our hospital for the last year. Methods: Eight patients diagnosed with HOCM by catheter examinations received a temporary DDD pacemaker, temporary septal branch occlusion, and a disopyramide intravenous infusion. The systolic pressure gradient of the left ventricular outflow tract was measured before and after the provocations, and then we decided which therapy was the best for each patient. Result: Two patients received PTSMA, one received a DDD pacemaker, and five received medical therapy. Three of the medical therapy patients gained a higher LVOTG, and for two of them their therapy was changed to PTSMA. Each of the LVOTGs were reduced to a theraputic level and good results were obtained. Finally, four patients received PTSMA, one received a DDD pacemaker, and three received medical therapy. Conclusion: There may be a difference between internal use and intravenous infusion in the effect of disopyramide. PTSMA was effective for these patients and considered to be an effective therapy for patients with HOCM.
| Original language | English |
|---|---|
| Pages (from-to) | 446-450 |
| Number of pages | 5 |
| Journal | Japanese Journal of Interventional Cardiology |
| Volume | 18 |
| Issue number | 5 |
| Publication status | Published - 2003 |
| Externally published | Yes |
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Keywords
- DDD pacing
- HOCM
- Myocardial ablation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Radiology Nuclear Medicine and imaging
Cite this
Treatment in Patients with Hypertrophic Obstructive Cardiomyopathy : A New Strategy used in our Hospital and the Results. / Yoshida, Masashi; Inoue, Ichiro; Kawagoe, Takuji; Ishihara, Masaharu; Shimatani, Yuji; Kurisu, Satoshi; Nishioka, Kenji; Umemura, Takashi; Nakamura, Shuji; Habara, Maoto.
In: Japanese Journal of Interventional Cardiology, Vol. 18, No. 5, 2003, p. 446-450.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment in Patients with Hypertrophic Obstructive Cardiomyopathy
T2 - A New Strategy used in our Hospital and the Results
AU - Yoshida, Masashi
AU - Inoue, Ichiro
AU - Kawagoe, Takuji
AU - Ishihara, Masaharu
AU - Shimatani, Yuji
AU - Kurisu, Satoshi
AU - Nishioka, Kenji
AU - Umemura, Takashi
AU - Nakamura, Shuji
AU - Habara, Maoto
PY - 2003
Y1 - 2003
N2 - Objective: In the treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM), the effects of drug therapy using negative inotropic drugs, percutaneous transluminal septal myocardial ablation (PTSMA), DDD pacemakers and surgical myectomy/myotomy are well recognized. In this study, we investigate a new treatment strategy used in our hospital for the last year. Methods: Eight patients diagnosed with HOCM by catheter examinations received a temporary DDD pacemaker, temporary septal branch occlusion, and a disopyramide intravenous infusion. The systolic pressure gradient of the left ventricular outflow tract was measured before and after the provocations, and then we decided which therapy was the best for each patient. Result: Two patients received PTSMA, one received a DDD pacemaker, and five received medical therapy. Three of the medical therapy patients gained a higher LVOTG, and for two of them their therapy was changed to PTSMA. Each of the LVOTGs were reduced to a theraputic level and good results were obtained. Finally, four patients received PTSMA, one received a DDD pacemaker, and three received medical therapy. Conclusion: There may be a difference between internal use and intravenous infusion in the effect of disopyramide. PTSMA was effective for these patients and considered to be an effective therapy for patients with HOCM.
AB - Objective: In the treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM), the effects of drug therapy using negative inotropic drugs, percutaneous transluminal septal myocardial ablation (PTSMA), DDD pacemakers and surgical myectomy/myotomy are well recognized. In this study, we investigate a new treatment strategy used in our hospital for the last year. Methods: Eight patients diagnosed with HOCM by catheter examinations received a temporary DDD pacemaker, temporary septal branch occlusion, and a disopyramide intravenous infusion. The systolic pressure gradient of the left ventricular outflow tract was measured before and after the provocations, and then we decided which therapy was the best for each patient. Result: Two patients received PTSMA, one received a DDD pacemaker, and five received medical therapy. Three of the medical therapy patients gained a higher LVOTG, and for two of them their therapy was changed to PTSMA. Each of the LVOTGs were reduced to a theraputic level and good results were obtained. Finally, four patients received PTSMA, one received a DDD pacemaker, and three received medical therapy. Conclusion: There may be a difference between internal use and intravenous infusion in the effect of disopyramide. PTSMA was effective for these patients and considered to be an effective therapy for patients with HOCM.
KW - DDD pacing
KW - HOCM
KW - Myocardial ablation
UR - http://www.scopus.com/inward/record.url?scp=0242642745&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242642745&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0242642745
VL - 18
SP - 446
EP - 450
JO - Japanese Journal of Interventional Cardiology
JF - Japanese Journal of Interventional Cardiology
SN - 0914-8922
IS - 5
ER -