Treat and repair strategy in patients with atrial septal defect and significant pulmonary arterial hypertension

Yasufumi Kijima, Teiji Akagi, Yoichi Takaya, Satoshi Akagi, Koji Nakagawa, Kengo Kusano, Shunji Sano, Hiroshi Itoh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: A therapeutic strategy in patients with atrial septal defect (ASD) and significant pulmonary arterial hypertension (PAH) remains controversial. This study aimed to assess the effect of PAH-specific medications and subsequent transcatheter shunt closure (ie, a treat and repair strategy) in these patients. Methods and Results: Among 646 patients with ASD, 22 patients (mean age of 56±20 years) who had PAH [mean pulmonary artery pressure ≥25 mmHg and pulmonary vascular resistance (PVR) ≥3 Wood units] underwent successful transcatheter ASD closure. Prior to the procedure, 8 patients received PAH-specific medications (PHM group) and 14 patients did not (non-PHM group). Initially, the PHM group had higher PVR compared with non-PHM group (9.6±3.8 vs. 4.2±1.0 Wood units, P

Original languageEnglish
Pages (from-to)227-234
Number of pages8
JournalCirculation Journal
Volume80
Issue number1
DOIs
Publication statusPublished - Dec 25 2015

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Atrial Heart Septal Defects
Pulmonary Hypertension
Vascular Resistance
Pulmonary Artery
Pressure

Keywords

  • Atrial septal defect
  • Catheter intervention
  • Pulmonary hypertension
  • Treat and repair strategy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Treat and repair strategy in patients with atrial septal defect and significant pulmonary arterial hypertension. / Kijima, Yasufumi; Akagi, Teiji; Takaya, Yoichi; Akagi, Satoshi; Nakagawa, Koji; Kusano, Kengo; Sano, Shunji; Itoh, Hiroshi.

In: Circulation Journal, Vol. 80, No. 1, 25.12.2015, p. 227-234.

Research output: Contribution to journalArticle

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