Abstract
Background: A therapeutic strategy in patients with atrial septal defect (ASD) and significant pulmonary arterial hypertension (PAH) remains controversial. This study aimed to assess the effect of PAH-specific medications and subsequent transcatheter shunt closure (ie, a treat and repair strategy) in these patients. Methods and Results: Among 646 patients with ASD, 22 patients (mean age of 56±20 years) who had PAH [mean pulmonary artery pressure ≥25 mmHg and pulmonary vascular resistance (PVR) ≥3 Wood units] underwent successful transcatheter ASD closure. Prior to the procedure, 8 patients received PAH-specific medications (PHM group) and 14 patients did not (non-PHM group). Initially, the PHM group had higher PVR compared with non-PHM group (9.6±3.8 vs. 4.2±1.0 Wood units, P
| Original language | English |
|---|---|
| Pages (from-to) | 227-234 |
| Number of pages | 8 |
| Journal | Circulation Journal |
| Volume | 80 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 25 2015 |
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Keywords
- Atrial septal defect
- Catheter intervention
- Pulmonary hypertension
- Treat and repair strategy
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Treat and repair strategy in patients with atrial septal defect and significant pulmonary arterial hypertension. / Kijima, Yasufumi; Akagi, Teiji; Takaya, Yoichi; Akagi, Satoshi; Nakagawa, Koji; Kusano, Kengo; Sano, Shunji; Itoh, Hiroshi.
In: Circulation Journal, Vol. 80, No. 1, 25.12.2015, p. 227-234.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treat and repair strategy in patients with atrial septal defect and significant pulmonary arterial hypertension
AU - Kijima, Yasufumi
AU - Akagi, Teiji
AU - Takaya, Yoichi
AU - Akagi, Satoshi
AU - Nakagawa, Koji
AU - Kusano, Kengo
AU - Sano, Shunji
AU - Itoh, Hiroshi
PY - 2015/12/25
Y1 - 2015/12/25
N2 - Background: A therapeutic strategy in patients with atrial septal defect (ASD) and significant pulmonary arterial hypertension (PAH) remains controversial. This study aimed to assess the effect of PAH-specific medications and subsequent transcatheter shunt closure (ie, a treat and repair strategy) in these patients. Methods and Results: Among 646 patients with ASD, 22 patients (mean age of 56±20 years) who had PAH [mean pulmonary artery pressure ≥25 mmHg and pulmonary vascular resistance (PVR) ≥3 Wood units] underwent successful transcatheter ASD closure. Prior to the procedure, 8 patients received PAH-specific medications (PHM group) and 14 patients did not (non-PHM group). Initially, the PHM group had higher PVR compared with non-PHM group (9.6±3.8 vs. 4.2±1.0 Wood units, P
AB - Background: A therapeutic strategy in patients with atrial septal defect (ASD) and significant pulmonary arterial hypertension (PAH) remains controversial. This study aimed to assess the effect of PAH-specific medications and subsequent transcatheter shunt closure (ie, a treat and repair strategy) in these patients. Methods and Results: Among 646 patients with ASD, 22 patients (mean age of 56±20 years) who had PAH [mean pulmonary artery pressure ≥25 mmHg and pulmonary vascular resistance (PVR) ≥3 Wood units] underwent successful transcatheter ASD closure. Prior to the procedure, 8 patients received PAH-specific medications (PHM group) and 14 patients did not (non-PHM group). Initially, the PHM group had higher PVR compared with non-PHM group (9.6±3.8 vs. 4.2±1.0 Wood units, P
KW - Atrial septal defect
KW - Catheter intervention
KW - Pulmonary hypertension
KW - Treat and repair strategy
UR - http://www.scopus.com/inward/record.url?scp=84951771317&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951771317&partnerID=8YFLogxK
U2 - 10.1253/circj.CJ-15-0599
DO - 10.1253/circj.CJ-15-0599
M3 - Article
C2 - 26567484
AN - SCOPUS:84951771317
VL - 80
SP - 227
EP - 234
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 1
ER -