Transport of trace elements in lenses of normal and hereditary cataract UPL rats

Tomohiro Nabekura, Takeshi Minami, Rieko Hirunuma, Shuichi Enomoto, Masayuki Tomohiro, Yoshimasa Ito, Shuji Kitagawa

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The multitracer technique was applied to the determination of the uptake of trace elements in the lenses of normal and hereditary cataract UPL rats to investigate the transport mechanisms of trace elements during cataract development. Be, Na, Sc, V, Cr, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Tc, Ru and Rh accumulate in normal and UPL cataract rat lenses. The rates of uptake of trace elements differ among species and also differ between normal and UPL rat lenses. The uptakes of V and Sr are greater in normal rat lenses, while the uptakes of Mn and Co are greater in UPL rat lenses. High concentrations of Zn are transported into normal rat lenses in comparison with other elements. However, the uptake of Se was highest in the lenses of UPL cataract rats. In addition, the difference in Se uptake between the normal and UPL rat lenses was greatest among the tested trace elements. The present study suggests that the transport characteristics of trace elements are different in the lenses of normal and UPL cataract rats. The different transport characteristics of trace elements in the lenses of normal and UPL cataract rats, especially the higher accumulation of Se in UPL rat lenses, may be implicated in cataract development.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalToxicology
Volume191
Issue number2-3
DOIs
Publication statusPublished - Sep 30 2003

Keywords

  • Cataract
  • Crystalline lens
  • Multitracer
  • Selenium
  • Trace element

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'Transport of trace elements in lenses of normal and hereditary cataract UPL rats'. Together they form a unique fingerprint.

Cite this