Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice

Z. Gu, K. Akiyama, X. Ma, H. Zhang, X. Feng, G. Yao, Y. Hou, L. Lu, G. S. Gilkeson, R. M. Silver, X. Zeng, S. Shi, L. Sun

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91 Citations (Scopus)

Abstract

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, which, despite the advances in immunosuppressive medical therapies, remains potentially fatal in some patients, especially in treatment-refractory patients. This study found that transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) has the same therapeutic effect as transplantation of bone marrow mesenchymal stem cells (BM-MSCs), which has been reported to be efficient in treating SLE-related symptoms in MRL/lpr mice. Multi-treatment (at the 18th, 19th, and 20th weeks of age) of 1 - 106 UC-MSCs was able to decrease the levels of 24-h proteinuria, serum creatinine, and anti-double-stranded DNA (dsDNA) antibody, and the extent of renal injury such as crescent formation in MRL/lpr mice. A lower, but still significant, reduction in these parameters was also observed in mice receiving a single dose of UC-MSCs (at the 18th week). UC-MSCs treatment also inhibited expression of monocyte chemotactic protein-1 (MCP-1) and high-mobility group box 1 (HMGB-1) expression in a similar fashion. UC-MSCs labeled with carboxyfluorescein diacetate succinimidyl ester (CFSE) were found in the lungs and kidneys 1 week post infusion. In addition, after 11 weeks post UC-MSCs infusion, human cells were found in kidney of UC-MSCs-treated mice. These findings indicated that UC-MSCs transplantation might be a potentially promising approach in the treatment of lupus nephritis, possibly by inhibiting MCP-1 and HMGB-1 production. Lupus (2010) 19, 1502-1514.

Original languageEnglish
Pages (from-to)1502-1514
Number of pages13
JournalLupus
Volume19
Issue number13
DOIs
Publication statusPublished - Nov 1 2010
Externally publishedYes

Keywords

  • high-mobility group box 1
  • lupus nephritis
  • monocyte chemotactic protein-1
  • regulatory T cell
  • systemic lupus erythematosus
  • umbilical cord mesenchymal stem cell

ASJC Scopus subject areas

  • Rheumatology

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  • Cite this

    Gu, Z., Akiyama, K., Ma, X., Zhang, H., Feng, X., Yao, G., Hou, Y., Lu, L., Gilkeson, G. S., Silver, R. M., Zeng, X., Shi, S., & Sun, L. (2010). Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice. Lupus, 19(13), 1502-1514. https://doi.org/10.1177/0961203310373782