TY - JOUR
T1 - Transmural cellular heterogeneity in myocardial electromechanics
AU - Khokhlova, Anastasia
AU - Balakina-Vikulova, Nathalie
AU - Katsnelson, Leonid
AU - Iribe, Gentaro
AU - Solovyova, Olga
N1 - Funding Information:
Acknowledgments This work was supported by RF Government Resolution #211 of March 16, 2013 and Program of the RAS Presidium #I.33G.
Publisher Copyright:
© 2017, The Physiological Society of Japan and Springer Japan.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the differences in the action potential and contraction between the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes are essential to produce the differences in Ca2+ transients and contraction profiles via cooperative mechanisms of mechano-calcium-electric feedback and may further slightly modulate transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in the mechanical load than EPI cells. These data are important for understanding the behavior of cardiomyocytes in the intact heart.
AB - Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the differences in the action potential and contraction between the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes are essential to produce the differences in Ca2+ transients and contraction profiles via cooperative mechanisms of mechano-calcium-electric feedback and may further slightly modulate transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in the mechanical load than EPI cells. These data are important for understanding the behavior of cardiomyocytes in the intact heart.
KW - Cardiac modeling
KW - Cardiac transmural heterogeneity
KW - Cardiomyocyte
KW - Electromechanical coupling
KW - Mechano-calcium-electric feedback
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U2 - 10.1007/s12576-017-0541-0
DO - 10.1007/s12576-017-0541-0
M3 - Article
C2 - 28573594
AN - SCOPUS:85016422654
SN - 1880-6546
VL - 68
SP - 387
EP - 413
JO - Journal of Physiological Sciences
JF - Journal of Physiological Sciences
IS - 4
ER -