Transition in the etiology of liver cirrhosis in Japan: a nationwide survey

Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH

Research output: Contribution to journalArticle

Abstract

Background: To assess the recent real-world changes in the etiologies of liver cirrhosis (LC) in Japan, we conducted a nationwide survey in the annual meeting of the Japan Society of Hepatology (JSH). Methods: We investigated the etiologies of LC patients accumulated from 68 participants in 79 institutions (N = 48,621). We next assessed changing trends in the etiologies of LC by analyzing cases in which the year of diagnosis was available (N = 45,834). We further evaluated the transition in the real number of newly identified LC patients by assessing data from 36 hospitals with complete datasets for 2008–2016 (N = 18,358). Results: In the overall data, HCV infection (48.2%) was the leading cause of LC in Japan, and HBV infection (11.5%) was the third-most common cause. Regarding the transition in the etiologies of LC, the contribution of viral hepatitis-related LC dropped from 73.4 to 49.7%. Among the non-viral etiologies, alcoholic-related disease (ALD) and nonalcoholic steatohepatitis (NASH)-related LC showed a notable increase (from 13.7 to 24.9% and from 2.0 to 9.1%, respectively). Regarding the real numbers of newly diagnosed patients from 2008 to 2016, the numbers of patients with viral hepatitis-related LC decreased, while the numbers of patients with non-viral LC increased. Conclusions: HCV has remained the main cause of LC in Japan; however, the contribution of viral hepatitis as an etiology of LC is suggested to have been decreasing. In addition, non-viral LC, such as ALD-related LC and NASH-related LC, is suggested to have increased as etiologies of LC in Japan.

Original languageEnglish
JournalJournal of Gastroenterology
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Liver Cirrhosis
Japan
Hepatitis
Surveys and Questionnaires
Gastroenterology
Infection

Keywords

  • Cirrhosis
  • Etiology
  • Nationwide survey
  • Viral hepatitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH (Accepted/In press). Transition in the etiology of liver cirrhosis in Japan: a nationwide survey. Journal of Gastroenterology. https://doi.org/10.1007/s00535-019-01645-y

Transition in the etiology of liver cirrhosis in Japan : a nationwide survey. / Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH.

In: Journal of Gastroenterology, 01.01.2019.

Research output: Contribution to journalArticle

Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH. Transition in the etiology of liver cirrhosis in Japan: a nationwide survey. Journal of Gastroenterology. 2019 Jan 1. https://doi.org/10.1007/s00535-019-01645-y
Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH. / Transition in the etiology of liver cirrhosis in Japan : a nationwide survey. In: Journal of Gastroenterology. 2019.
@article{e8f155b76e814fbb84fecd99004d377c,
title = "Transition in the etiology of liver cirrhosis in Japan: a nationwide survey",
abstract = "Background: To assess the recent real-world changes in the etiologies of liver cirrhosis (LC) in Japan, we conducted a nationwide survey in the annual meeting of the Japan Society of Hepatology (JSH). Methods: We investigated the etiologies of LC patients accumulated from 68 participants in 79 institutions (N = 48,621). We next assessed changing trends in the etiologies of LC by analyzing cases in which the year of diagnosis was available (N = 45,834). We further evaluated the transition in the real number of newly identified LC patients by assessing data from 36 hospitals with complete datasets for 2008–2016 (N = 18,358). Results: In the overall data, HCV infection (48.2{\%}) was the leading cause of LC in Japan, and HBV infection (11.5{\%}) was the third-most common cause. Regarding the transition in the etiologies of LC, the contribution of viral hepatitis-related LC dropped from 73.4 to 49.7{\%}. Among the non-viral etiologies, alcoholic-related disease (ALD) and nonalcoholic steatohepatitis (NASH)-related LC showed a notable increase (from 13.7 to 24.9{\%} and from 2.0 to 9.1{\%}, respectively). Regarding the real numbers of newly diagnosed patients from 2008 to 2016, the numbers of patients with viral hepatitis-related LC decreased, while the numbers of patients with non-viral LC increased. Conclusions: HCV has remained the main cause of LC in Japan; however, the contribution of viral hepatitis as an etiology of LC is suggested to have been decreasing. In addition, non-viral LC, such as ALD-related LC and NASH-related LC, is suggested to have increased as etiologies of LC in Japan.",
keywords = "Cirrhosis, Etiology, Nationwide survey, Viral hepatitis",
author = "{Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH} and Hirayuki Enomoto and Yoshiyuki Ueno and Yoichi Hiasa and Hiroki Nishikawa and Shuhei Hige and Yasuhiro Takikawa and Makiko Taniai and Toru Ishikawa and Kohichiroh Yasui and Akinobu Takaki and Koichi Takaguchi and Akio Ido and Masayuki Kurosaki and Tatsuya Kanto and Shuhei Nishiguchi",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00535-019-01645-y",
language = "English",
journal = "Journal of Gastroenterology",
issn = "0944-1174",
publisher = "Springer Japan",

}

TY - JOUR

T1 - Transition in the etiology of liver cirrhosis in Japan

T2 - a nationwide survey

AU - Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH

AU - Enomoto, Hirayuki

AU - Ueno, Yoshiyuki

AU - Hiasa, Yoichi

AU - Nishikawa, Hiroki

AU - Hige, Shuhei

AU - Takikawa, Yasuhiro

AU - Taniai, Makiko

AU - Ishikawa, Toru

AU - Yasui, Kohichiroh

AU - Takaki, Akinobu

AU - Takaguchi, Koichi

AU - Ido, Akio

AU - Kurosaki, Masayuki

AU - Kanto, Tatsuya

AU - Nishiguchi, Shuhei

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: To assess the recent real-world changes in the etiologies of liver cirrhosis (LC) in Japan, we conducted a nationwide survey in the annual meeting of the Japan Society of Hepatology (JSH). Methods: We investigated the etiologies of LC patients accumulated from 68 participants in 79 institutions (N = 48,621). We next assessed changing trends in the etiologies of LC by analyzing cases in which the year of diagnosis was available (N = 45,834). We further evaluated the transition in the real number of newly identified LC patients by assessing data from 36 hospitals with complete datasets for 2008–2016 (N = 18,358). Results: In the overall data, HCV infection (48.2%) was the leading cause of LC in Japan, and HBV infection (11.5%) was the third-most common cause. Regarding the transition in the etiologies of LC, the contribution of viral hepatitis-related LC dropped from 73.4 to 49.7%. Among the non-viral etiologies, alcoholic-related disease (ALD) and nonalcoholic steatohepatitis (NASH)-related LC showed a notable increase (from 13.7 to 24.9% and from 2.0 to 9.1%, respectively). Regarding the real numbers of newly diagnosed patients from 2008 to 2016, the numbers of patients with viral hepatitis-related LC decreased, while the numbers of patients with non-viral LC increased. Conclusions: HCV has remained the main cause of LC in Japan; however, the contribution of viral hepatitis as an etiology of LC is suggested to have been decreasing. In addition, non-viral LC, such as ALD-related LC and NASH-related LC, is suggested to have increased as etiologies of LC in Japan.

AB - Background: To assess the recent real-world changes in the etiologies of liver cirrhosis (LC) in Japan, we conducted a nationwide survey in the annual meeting of the Japan Society of Hepatology (JSH). Methods: We investigated the etiologies of LC patients accumulated from 68 participants in 79 institutions (N = 48,621). We next assessed changing trends in the etiologies of LC by analyzing cases in which the year of diagnosis was available (N = 45,834). We further evaluated the transition in the real number of newly identified LC patients by assessing data from 36 hospitals with complete datasets for 2008–2016 (N = 18,358). Results: In the overall data, HCV infection (48.2%) was the leading cause of LC in Japan, and HBV infection (11.5%) was the third-most common cause. Regarding the transition in the etiologies of LC, the contribution of viral hepatitis-related LC dropped from 73.4 to 49.7%. Among the non-viral etiologies, alcoholic-related disease (ALD) and nonalcoholic steatohepatitis (NASH)-related LC showed a notable increase (from 13.7 to 24.9% and from 2.0 to 9.1%, respectively). Regarding the real numbers of newly diagnosed patients from 2008 to 2016, the numbers of patients with viral hepatitis-related LC decreased, while the numbers of patients with non-viral LC increased. Conclusions: HCV has remained the main cause of LC in Japan; however, the contribution of viral hepatitis as an etiology of LC is suggested to have been decreasing. In addition, non-viral LC, such as ALD-related LC and NASH-related LC, is suggested to have increased as etiologies of LC in Japan.

KW - Cirrhosis

KW - Etiology

KW - Nationwide survey

KW - Viral hepatitis

UR - http://www.scopus.com/inward/record.url?scp=85076200093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076200093&partnerID=8YFLogxK

U2 - 10.1007/s00535-019-01645-y

DO - 10.1007/s00535-019-01645-y

M3 - Article

C2 - 31768801

AN - SCOPUS:85076200093

JO - Journal of Gastroenterology

JF - Journal of Gastroenterology

SN - 0944-1174

ER -