Abstract
Background: To assess the recent real-world changes in the etiologies of liver cirrhosis (LC) in Japan, we conducted a nationwide survey in the annual meeting of the Japan Society of Hepatology (JSH). Methods: We investigated the etiologies of LC patients accumulated from 68 participants in 79 institutions (N = 48,621). We next assessed changing trends in the etiologies of LC by analyzing cases in which the year of diagnosis was available (N = 45,834). We further evaluated the transition in the real number of newly identified LC patients by assessing data from 36 hospitals with complete datasets for 2008–2016 (N = 18,358). Results: In the overall data, HCV infection (48.2%) was the leading cause of LC in Japan, and HBV infection (11.5%) was the third-most common cause. Regarding the transition in the etiologies of LC, the contribution of viral hepatitis-related LC dropped from 73.4 to 49.7%. Among the non-viral etiologies, alcoholic-related disease (ALD) and nonalcoholic steatohepatitis (NASH)-related LC showed a notable increase (from 13.7 to 24.9% and from 2.0 to 9.1%, respectively). Regarding the real numbers of newly diagnosed patients from 2008 to 2016, the numbers of patients with viral hepatitis-related LC decreased, while the numbers of patients with non-viral LC increased. Conclusions: HCV has remained the main cause of LC in Japan; however, the contribution of viral hepatitis as an etiology of LC is suggested to have been decreasing. In addition, non-viral LC, such as ALD-related LC and NASH-related LC, is suggested to have increased as etiologies of LC in Japan.
| Original language | English |
|---|---|
| Journal | Journal of Gastroenterology |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2019 |
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Keywords
- Cirrhosis
- Etiology
- Nationwide survey
- Viral hepatitis
ASJC Scopus subject areas
- Gastroenterology
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Transition in the etiology of liver cirrhosis in Japan : a nationwide survey. / Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH.
In: Journal of Gastroenterology, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transition in the etiology of liver cirrhosis in Japan
T2 - a nationwide survey
AU - Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH
AU - Enomoto, Hirayuki
AU - Ueno, Yoshiyuki
AU - Hiasa, Yoichi
AU - Nishikawa, Hiroki
AU - Hige, Shuhei
AU - Takikawa, Yasuhiro
AU - Taniai, Makiko
AU - Ishikawa, Toru
AU - Yasui, Kohichiroh
AU - Takaki, Akinobu
AU - Takaguchi, Koichi
AU - Ido, Akio
AU - Kurosaki, Masayuki
AU - Kanto, Tatsuya
AU - Nishiguchi, Shuhei
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: To assess the recent real-world changes in the etiologies of liver cirrhosis (LC) in Japan, we conducted a nationwide survey in the annual meeting of the Japan Society of Hepatology (JSH). Methods: We investigated the etiologies of LC patients accumulated from 68 participants in 79 institutions (N = 48,621). We next assessed changing trends in the etiologies of LC by analyzing cases in which the year of diagnosis was available (N = 45,834). We further evaluated the transition in the real number of newly identified LC patients by assessing data from 36 hospitals with complete datasets for 2008–2016 (N = 18,358). Results: In the overall data, HCV infection (48.2%) was the leading cause of LC in Japan, and HBV infection (11.5%) was the third-most common cause. Regarding the transition in the etiologies of LC, the contribution of viral hepatitis-related LC dropped from 73.4 to 49.7%. Among the non-viral etiologies, alcoholic-related disease (ALD) and nonalcoholic steatohepatitis (NASH)-related LC showed a notable increase (from 13.7 to 24.9% and from 2.0 to 9.1%, respectively). Regarding the real numbers of newly diagnosed patients from 2008 to 2016, the numbers of patients with viral hepatitis-related LC decreased, while the numbers of patients with non-viral LC increased. Conclusions: HCV has remained the main cause of LC in Japan; however, the contribution of viral hepatitis as an etiology of LC is suggested to have been decreasing. In addition, non-viral LC, such as ALD-related LC and NASH-related LC, is suggested to have increased as etiologies of LC in Japan.
AB - Background: To assess the recent real-world changes in the etiologies of liver cirrhosis (LC) in Japan, we conducted a nationwide survey in the annual meeting of the Japan Society of Hepatology (JSH). Methods: We investigated the etiologies of LC patients accumulated from 68 participants in 79 institutions (N = 48,621). We next assessed changing trends in the etiologies of LC by analyzing cases in which the year of diagnosis was available (N = 45,834). We further evaluated the transition in the real number of newly identified LC patients by assessing data from 36 hospitals with complete datasets for 2008–2016 (N = 18,358). Results: In the overall data, HCV infection (48.2%) was the leading cause of LC in Japan, and HBV infection (11.5%) was the third-most common cause. Regarding the transition in the etiologies of LC, the contribution of viral hepatitis-related LC dropped from 73.4 to 49.7%. Among the non-viral etiologies, alcoholic-related disease (ALD) and nonalcoholic steatohepatitis (NASH)-related LC showed a notable increase (from 13.7 to 24.9% and from 2.0 to 9.1%, respectively). Regarding the real numbers of newly diagnosed patients from 2008 to 2016, the numbers of patients with viral hepatitis-related LC decreased, while the numbers of patients with non-viral LC increased. Conclusions: HCV has remained the main cause of LC in Japan; however, the contribution of viral hepatitis as an etiology of LC is suggested to have been decreasing. In addition, non-viral LC, such as ALD-related LC and NASH-related LC, is suggested to have increased as etiologies of LC in Japan.
KW - Cirrhosis
KW - Etiology
KW - Nationwide survey
KW - Viral hepatitis
UR - http://www.scopus.com/inward/record.url?scp=85076200093&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85076200093&partnerID=8YFLogxK
U2 - 10.1007/s00535-019-01645-y
DO - 10.1007/s00535-019-01645-y
M3 - Article
C2 - 31768801
AN - SCOPUS:85076200093
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
SN - 0944-1174
ER -