Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation

Isao Yoshida, Keitaro Matsuo, Takanori Teshima, Daigo Hashimoto, Yasushi Tanimoto, Mine Harada, Mitsune Tanimoto

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

BACKGROUND: Allogeneic peripheral blood progenitor cell (PBPC) transplantation requires granulocyte-colony-stimulating factor (G-CSF) administration to mobilize PBPCs in healthy donors. The effects of G-CSF on pulmonary functions, however, have not been clearly elucidated in PBPC donors. STUDY DESIGN AND METHODS: Respiratory status by measurements of arterial blood gas was prospectively evaluated serially in 25 healthy donors (9 men, 16 women; age, 18-61 years) administered a dose of 10 μg per kg for 5 days. RESULTS: White blood cell (WBC) counts increased in all the subjects after G-CSF administration; means on Days 0, 3, and 5 were 6 × 109, 33.4 × 109, and 33.6 × 109 per L, respectively. The mean PaO2 values on the respective days were 93.1, 85.8, and 81.8 mmHg, and these changes were significant (p <0.0001), remaining significant after adjustment for the WBC count. Levels of both PaCO2 and AaDO2 were significantly higher after G-CSF administration than those before G-CSF administration (p <0.0001 and p = 0.0004, respectively). SaO2 was significantly decreased after G-CSF administration (p = 0.0002). Age was identified as a significant predictive factor for the increase of AaDO2 and PaO2 decline. These observations clearly indicate that the gas exchange was significantly affected during G-CSF administration in healthy PBPC donors. CONCLUSION: Considering an increasing use of PBPC mobilization by G-CSF, careful monitoring of the respiratory status is important to ensure safety of PBPC donors, especially elderly donors.

Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalTransfusion
Volume46
Issue number2
DOIs
Publication statusPublished - Feb 2006
Externally publishedYes

Fingerprint

Cell Transplantation
Granulocyte Colony-Stimulating Factor
Blood Cells
Stem Cells
Tissue Donors
Leukocyte Count
Gases
Safety
Lung

ASJC Scopus subject areas

  • Hematology
  • Immunology

Cite this

Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation. / Yoshida, Isao; Matsuo, Keitaro; Teshima, Takanori; Hashimoto, Daigo; Tanimoto, Yasushi; Harada, Mine; Tanimoto, Mitsune.

In: Transfusion, Vol. 46, No. 2, 02.2006, p. 186-192.

Research output: Contribution to journalArticle

Yoshida, Isao ; Matsuo, Keitaro ; Teshima, Takanori ; Hashimoto, Daigo ; Tanimoto, Yasushi ; Harada, Mine ; Tanimoto, Mitsune. / Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation. In: Transfusion. 2006 ; Vol. 46, No. 2. pp. 186-192.
@article{57246dd722004a8e9e05ffe3f7ef837c,
title = "Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation",
abstract = "BACKGROUND: Allogeneic peripheral blood progenitor cell (PBPC) transplantation requires granulocyte-colony-stimulating factor (G-CSF) administration to mobilize PBPCs in healthy donors. The effects of G-CSF on pulmonary functions, however, have not been clearly elucidated in PBPC donors. STUDY DESIGN AND METHODS: Respiratory status by measurements of arterial blood gas was prospectively evaluated serially in 25 healthy donors (9 men, 16 women; age, 18-61 years) administered a dose of 10 μg per kg for 5 days. RESULTS: White blood cell (WBC) counts increased in all the subjects after G-CSF administration; means on Days 0, 3, and 5 were 6 × 109, 33.4 × 109, and 33.6 × 109 per L, respectively. The mean PaO2 values on the respective days were 93.1, 85.8, and 81.8 mmHg, and these changes were significant (p <0.0001), remaining significant after adjustment for the WBC count. Levels of both PaCO2 and AaDO2 were significantly higher after G-CSF administration than those before G-CSF administration (p <0.0001 and p = 0.0004, respectively). SaO2 was significantly decreased after G-CSF administration (p = 0.0002). Age was identified as a significant predictive factor for the increase of AaDO2 and PaO2 decline. These observations clearly indicate that the gas exchange was significantly affected during G-CSF administration in healthy PBPC donors. CONCLUSION: Considering an increasing use of PBPC mobilization by G-CSF, careful monitoring of the respiratory status is important to ensure safety of PBPC donors, especially elderly donors.",
author = "Isao Yoshida and Keitaro Matsuo and Takanori Teshima and Daigo Hashimoto and Yasushi Tanimoto and Mine Harada and Mitsune Tanimoto",
year = "2006",
month = "2",
doi = "10.1111/j.1537-2995.2006.00700.x",
language = "English",
volume = "46",
pages = "186--192",
journal = "Transfusion",
issn = "0041-1132",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation

AU - Yoshida, Isao

AU - Matsuo, Keitaro

AU - Teshima, Takanori

AU - Hashimoto, Daigo

AU - Tanimoto, Yasushi

AU - Harada, Mine

AU - Tanimoto, Mitsune

PY - 2006/2

Y1 - 2006/2

N2 - BACKGROUND: Allogeneic peripheral blood progenitor cell (PBPC) transplantation requires granulocyte-colony-stimulating factor (G-CSF) administration to mobilize PBPCs in healthy donors. The effects of G-CSF on pulmonary functions, however, have not been clearly elucidated in PBPC donors. STUDY DESIGN AND METHODS: Respiratory status by measurements of arterial blood gas was prospectively evaluated serially in 25 healthy donors (9 men, 16 women; age, 18-61 years) administered a dose of 10 μg per kg for 5 days. RESULTS: White blood cell (WBC) counts increased in all the subjects after G-CSF administration; means on Days 0, 3, and 5 were 6 × 109, 33.4 × 109, and 33.6 × 109 per L, respectively. The mean PaO2 values on the respective days were 93.1, 85.8, and 81.8 mmHg, and these changes were significant (p <0.0001), remaining significant after adjustment for the WBC count. Levels of both PaCO2 and AaDO2 were significantly higher after G-CSF administration than those before G-CSF administration (p <0.0001 and p = 0.0004, respectively). SaO2 was significantly decreased after G-CSF administration (p = 0.0002). Age was identified as a significant predictive factor for the increase of AaDO2 and PaO2 decline. These observations clearly indicate that the gas exchange was significantly affected during G-CSF administration in healthy PBPC donors. CONCLUSION: Considering an increasing use of PBPC mobilization by G-CSF, careful monitoring of the respiratory status is important to ensure safety of PBPC donors, especially elderly donors.

AB - BACKGROUND: Allogeneic peripheral blood progenitor cell (PBPC) transplantation requires granulocyte-colony-stimulating factor (G-CSF) administration to mobilize PBPCs in healthy donors. The effects of G-CSF on pulmonary functions, however, have not been clearly elucidated in PBPC donors. STUDY DESIGN AND METHODS: Respiratory status by measurements of arterial blood gas was prospectively evaluated serially in 25 healthy donors (9 men, 16 women; age, 18-61 years) administered a dose of 10 μg per kg for 5 days. RESULTS: White blood cell (WBC) counts increased in all the subjects after G-CSF administration; means on Days 0, 3, and 5 were 6 × 109, 33.4 × 109, and 33.6 × 109 per L, respectively. The mean PaO2 values on the respective days were 93.1, 85.8, and 81.8 mmHg, and these changes were significant (p <0.0001), remaining significant after adjustment for the WBC count. Levels of both PaCO2 and AaDO2 were significantly higher after G-CSF administration than those before G-CSF administration (p <0.0001 and p = 0.0004, respectively). SaO2 was significantly decreased after G-CSF administration (p = 0.0002). Age was identified as a significant predictive factor for the increase of AaDO2 and PaO2 decline. These observations clearly indicate that the gas exchange was significantly affected during G-CSF administration in healthy PBPC donors. CONCLUSION: Considering an increasing use of PBPC mobilization by G-CSF, careful monitoring of the respiratory status is important to ensure safety of PBPC donors, especially elderly donors.

UR - http://www.scopus.com/inward/record.url?scp=33644849580&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644849580&partnerID=8YFLogxK

U2 - 10.1111/j.1537-2995.2006.00700.x

DO - 10.1111/j.1537-2995.2006.00700.x

M3 - Article

VL - 46

SP - 186

EP - 192

JO - Transfusion

JF - Transfusion

SN - 0041-1132

IS - 2

ER -