Transient increase of TUNEL-positive cells on postnatal day 20 in the developing rat olfactory bulb

Kyoko Saito, Shouichiro Saito, Kazuyuki Taniguchi, Naoto Kobayashi, Takehiro Terashita, Tetsuya Shimokawa, Katsumi Mominoki, Kyojy Miyawaki, Jie Chen, Shuang Yan Gao, Chun Yu Li, Seiji Matsuda

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In the developing central nervous system, apoptosis plays an important role in the normal organization of the neuronal circuit. The timing of neurogenesis, proliferation, and migration of the neurons in the developing olfactory bulb (OB) is well studied; however, the involvement of apoptosis in this process is not fully understood. In this study, we examined the changes in the distribution and the number of apoptotic cells in the rat OB during embryonic and postnatal periods, by using terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end-labeling (TUNEL) staining. Although the number of TUNEL-positive cells was relatively small during the embryonic period, it gradually increased after birth, and peaked on postnatal day 20 with statistical significance, especially in the granule cell layer of the main OB. This transient increase of TUNEL-positive cells on postnatal day 20 may be involved in a critical event during maturation of the OB.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalNeuroscience Research
Volume50
Issue number2
DOIs
Publication statusPublished - Oct 1 2004
Externally publishedYes

Keywords

  • Apoptosis
  • Development
  • Olfactory bulb
  • Rat
  • TUNEL staining

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Transient increase of TUNEL-positive cells on postnatal day 20 in the developing rat olfactory bulb'. Together they form a unique fingerprint.

Cite this