Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp. isolated from Cinchona pubescens

Hirotaka Shibuya, Chinami Kitamura, Shoji Maehara, Marie Nagahata, Hendig Winarno, Partomuan Simanjuntak, Hye Sook Kim, Yusuke Wataya, Kazuyoshi Ohashi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • Antimalarial activity
  • Cinchona alkaloid
  • Cinchona pubescens
  • Endophyte
  • Microbial transformation
  • Xylaria sp.

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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