Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp. isolated from Cinchona pubescens

Hirotaka Shibuya, Chinami Kitamura, Shoji Maehara, Marie Nagahata, Hendig Winarno, Partomuan Simanjuntak, Hye-Sook Kim, Yusuke Wataya, Kazuyoshi Ohashi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 2003

Fingerprint

Cinchona
Cinchona Alkaloids
Fungi
Oxides
Derivatives
Quinidine
Quinine

Keywords

  • Antimalarial activity
  • Cinchona alkaloid
  • Cinchona pubescens
  • Endophyte
  • Microbial transformation
  • Xylaria sp.

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp. isolated from Cinchona pubescens. / Shibuya, Hirotaka; Kitamura, Chinami; Maehara, Shoji; Nagahata, Marie; Winarno, Hendig; Simanjuntak, Partomuan; Kim, Hye-Sook; Wataya, Yusuke; Ohashi, Kazuyoshi.

In: Chemical and Pharmaceutical Bulletin, Vol. 51, No. 1, 01.2003, p. 71-74.

Research output: Contribution to journalArticle

Shibuya, H, Kitamura, C, Maehara, S, Nagahata, M, Winarno, H, Simanjuntak, P, Kim, H-S, Wataya, Y & Ohashi, K 2003, 'Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp. isolated from Cinchona pubescens', Chemical and Pharmaceutical Bulletin, vol. 51, no. 1, pp. 71-74. https://doi.org/10.1248/cpb.51.71
Shibuya, Hirotaka ; Kitamura, Chinami ; Maehara, Shoji ; Nagahata, Marie ; Winarno, Hendig ; Simanjuntak, Partomuan ; Kim, Hye-Sook ; Wataya, Yusuke ; Ohashi, Kazuyoshi. / Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp. isolated from Cinchona pubescens. In: Chemical and Pharmaceutical Bulletin. 2003 ; Vol. 51, No. 1. pp. 71-74.
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