Transcriptional targets in adipocyte biology

Evan Rosen, Jun Eguchi, Zhao Xu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The global burden of metabolic disease demands that we develop new therapeutic strategies. Many of these approaches may center on manipulating the behavior of adipocytes, which contribute directly and indirectly to a host of disease processes including obesity and type 2 diabetes. One way to achieve this goal will be to alter key transcriptional pathways in fat cells, such as those regulating glucose uptake, lipid handling, or adipokine secretion. In this review, we look at what is known about how adipocytes govern their physiology at the gene expression level, and discuss novel ways that we can accelerate our understanding of this area.

Original languageEnglish
Pages (from-to)975-986
Number of pages12
JournalExpert Opinion on Therapeutic Targets
Volume13
Issue number8
DOIs
Publication statusPublished - Aug 2009
Externally publishedYes

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Keywords

  • Adipocytes
  • Adipogenesis
  • Adipokines
  • Lipogenesis
  • Lipolysis

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

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