Transcriptional activation of mRNA of intercellular adhesion molecule 1 and induction of its cell surface expression in normal human gingival fibroblasts by Mycoplasma salivarium and Mycoplasma fermentans

Li Dong, Ken Ichiro Shibata, Yoshihiko Sawa, Akira Hasebe, Yuji Yamaoka, Shigemitsu Yoshida, Tsuguo Watanabe

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22 Citations (Scopus)


Lipoproteins in the cell membranes of both Mycoplasma salivarium and Mycoplasma fermentans were demonstrated to trigger the transcription of intercellular adhesion molecule-1 mRNA in normal fibroblasts isolated from human gingival tissue and to induce its cell surface expression by a mechanism distinct from that of Escherichia coli lipopolysaccharide. The lipid moiety of the lipoproteins was suggested to play a key role in the expression of the activity.

Original languageEnglish
Pages (from-to)3061-3065
Number of pages5
JournalInfection and Immunity
Issue number6
Publication statusPublished - Jun 1 1999


ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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