Transcoronary cell infusion with the stop-flow technique in children with single-ventricle physiology

Takahiro Eitoku, Kenji Baba, Maiko Kondou, Yoshihiko Kurita, Yousuke Fukushima, Kenta Hirai, Shinichi Ohtsuki, Shuta Ishigami, Shunji Sano, Hidemasa Oh

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Almost all reports on cardiac regeneration therapy have referred to adults, and only a few have focused on transcoronary infusion of cardiac progenitor cells using the stop-flow technique in children. Methods: Intracoronary autologous cardiosphere-derived cell (CDC) transfer was conducted at Okayama University as a phase 1 clinical trial for seven patients with hypoplastic left heart syndrome between January 2011 and December 2012, and as a phase 2 clinical trial for 34 patients with single-ventricle physiology between July 2013 and March 2015. Results: A total of 41 patients with single-ventricle physiology underwent transcoronary infusion of CDC with the stop-flow technique. The median age was 33 months (range, 5–70 months) and the median weight was 10.1 kg (range, 4.1–16.0 kg). Transient adverse events occurred during the procedure, including ST-segment elevation or depression, hypotension, bradycardia, and coronary artery vasospasm. All patients completely recovered. There were no major procedure-related adverse events. In this study, transcoronary infusion of CDC using the stop-flow technique was successfully completed in all patients. Conclusion: Transcoronary infusion of CDC using the stop-flow technique in children is a feasible and safe procedure.

Original languageEnglish
Pages (from-to)240-246
Number of pages7
JournalPediatrics International
Volume60
Issue number3
DOIs
Publication statusPublished - Mar 2018
Externally publishedYes

Keywords

  • congenital heart disease
  • regeneration therapy
  • stop-flow technique
  • temporary occlusion balloon
  • transcoronary infusion

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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