TY - JOUR
T1 - Trajectory of body mass index and height changes from childhood to adolescence
T2 - a nationwide birth cohort in Japan
AU - Matsumoto, Naomi
AU - Kubo, Toshihide
AU - Nakamura, Kazue
AU - Mitsuhashi, Toshiharu
AU - Takeuchi, Akihito
AU - Tsukahara, Hirokazu
AU - Yorifuji, Takashi
N1 - Funding Information:
We are grateful to Dr. Yoshiya Ito, professor of Department of Clinical Medicine, Hokkaido Red Cross College of Nursing, for his valuable advice in converting to Z-scores using the LMS method. We also thank Yoko Oka and Saori Irie, Okayama University, for help with data collection. This work was supported by JSPS KAKENHI Grant Number JP20K10498. We thank Edanz (http://jp.edanz.com/ac) for editing a draft of this manuscript.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - To investigate the dynamics of body mass index (BMI) and height changes in childhood leading to obesity in adolescents. BMI Z-scores were calculated using the LMS (lambda–mu–sigma) method based on yearly height and weight information (age 1.5–15 years) from a nationwide Japanese birth cohort that started in 2001 (n = 26,711). We delineated the trajectories of BMI and height changes leading to obesity at age 15 years using mixed effect models. Children who became obese at the age of 15 years kept relatively high BMI z-scores through childhood for both genders, and had an increasing trend over time as opposed to the normal weight group, with an increasing slope during puberty. Early adiposity rebound was associated with overweight or obesity at the age of 15 years. Age at peak height velocity (APHV) occurred earlier in the obese/overweight group at age 15 years than in the normal weight group, and occurred later in the underweight group. Obese adolescents experienced early adiposity rebound timing and maintained a serial BMI z-score increase throughout childhood, with a greater slope at puberty. An earlier peak in height gain during puberty may have contributed to the observed patterns of BMI change.
AB - To investigate the dynamics of body mass index (BMI) and height changes in childhood leading to obesity in adolescents. BMI Z-scores were calculated using the LMS (lambda–mu–sigma) method based on yearly height and weight information (age 1.5–15 years) from a nationwide Japanese birth cohort that started in 2001 (n = 26,711). We delineated the trajectories of BMI and height changes leading to obesity at age 15 years using mixed effect models. Children who became obese at the age of 15 years kept relatively high BMI z-scores through childhood for both genders, and had an increasing trend over time as opposed to the normal weight group, with an increasing slope during puberty. Early adiposity rebound was associated with overweight or obesity at the age of 15 years. Age at peak height velocity (APHV) occurred earlier in the obese/overweight group at age 15 years than in the normal weight group, and occurred later in the underweight group. Obese adolescents experienced early adiposity rebound timing and maintained a serial BMI z-score increase throughout childhood, with a greater slope at puberty. An earlier peak in height gain during puberty may have contributed to the observed patterns of BMI change.
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U2 - 10.1038/s41598-021-02464-z
DO - 10.1038/s41598-021-02464-z
M3 - Article
C2 - 34837002
AN - SCOPUS:85119891291
SN - 2045-2322
VL - 11
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 23004
ER -
