Towards improvement of covalent neuraminidase inhibitors with anomeric substitution

Christopher J. Vavricka, Tatsuma Matsumoto, Hiromasa Kiyota

Research output: Contribution to journalShort survey

Abstract

Neuraminidase (NA) inhibitors are effective at treating and preventing infections caused by epidemic and pandemic influenza viruses. The first generation of influenza NA inhibitors were inspired by the structure of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid, a putative oxocarbenium ion transition state analogue. As a next-generation approach to influenza NA inhibitor design, irreversible inhibitors targeting influenza NA Tyr406 are now being explored. After proving the concept that influenza NA can be irreversibly inhibited by difluorosialic acids, substitution of the anomeric carboxy group was examined as a second novel strategy. Anomeric sulfo analogues of sialic acid (N-acetylneuraminic acid, NANA) were thereby synthesized and found to inhibit influenza NA with higher potency relative to that of the corresponding anomeric carboxy and phosphono compounds, via enhanced electrostatic interactions with the NA active site triarginyl cluster. The combination of these two novel approaches is now being pursued to produce improved irreversible NA inhibitors.

Original languageEnglish
Pages (from-to)E1-E5
JournalTrends in Glycoscience and Glycotechnology
Volume32
Issue number185
DOIs
Publication statusPublished - Jan 1 2020

Keywords

  • Anomeric sulfonate
  • Irreversible NA inhibitors
  • Neuraminidase
  • Sialidase

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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