Toward the second generation synthesis of aplyronine A: Stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling

Kenichi Kobayashi, Yusuke Fujii, Ichiro Hayakawa, Hideo Kigoshi

Research output: Contribution to journalArticle

20 Citations (Scopus)


An efficient synthesis of the C1-C19 segment of aplyronine A is described. Stereoselective construction of the C14-C15 (E)-trisubstituted double bond and the C13 stereocenter was achieved by using an asymmetric Nozaki-Hiyama-Kishi coupling.(Figure Presented)

Original languageEnglish
Pages (from-to)900-903
Number of pages4
JournalOrganic Letters
Issue number5
Publication statusPublished - Mar 4 2011


ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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