Toward a new molecular taxonomy of diffuse large b-cell lymphoma

Daisuke Ennishi, Eric D. Hsi, Christian Steidl, David W. Scott

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Diffuse large B-cell lymphoma (DLBCL) represents a grouping of clinically and biologically heterogeneous tumors. Application of advanced molecular technology has significantly expanded our knowledge of DLBCL pathobiology, allowing identification of subgroups with common, potentially targetable, biological themes. Here, we review the recent molecular analyses that could provide a paradigm shift to a new taxonomy, foundational to the rational transition to pre-cision medicine. We discuss how classification systems may be synthesized into a common taxonomy, drawing strength from the relationships between genetic alterations, gene expression, and tumor microenvironment. Finally, challenges to translating such a taxonomy to the clinic will be outlined.

Original languageEnglish
Pages (from-to)1267-1281
Number of pages15
JournalCancer discovery
Volume10
Issue number9
DOIs
Publication statusPublished - 2020
Externally publishedYes

ASJC Scopus subject areas

  • Oncology

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