Total synthesis of two possible diastereomers of (+)-sarcophytonolide C and its structural elucidation

Hiroyoshi Takamura, Kohei Iwamoto, Eiji Nakao, Isao Kadota

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Stereoselective and parallel total syntheses of two possible diastereomers of (+)-sarcophytonolide C have been accomplished. Macrolactonization and transannular ring-closing metathesis (RCM) were the key transformations. Detailed comparisons of their 1H and 13C NMR data and specific rotation with those of the natural product allowed the absolute configuration of (+)-sarcophytonolide C to be determined.

Original languageEnglish
Pages (from-to)1108-1111
Number of pages4
JournalOrganic Letters
Volume15
Issue number5
DOIs
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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