Total Synthesis of Sarcophytonolide H and Isosarcophytonolide D

Structural Revision of Isosarcophytonolide D and Structure-Antifouling Activity Relationship of Sarcophytonolide H

Hiroyoshi Takamura, Takahiro Kikuchi, Noriyuki Endo, Yuji Fukuda, Isao Kadota

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The first total syntheses of sarcophytonolide H and the originally proposed and correct structures of isosarcophytonolide D have been achieved via transannular ring-closing metathesis (RCM). These total syntheses culminated in the stereostructural confirmation of sarcophytonolide H and the reassignment of isosarcophytonolide D, respectively. The antifouling activity of the synthetic sarcophytonolide H and its analogues was also evaluated.

Original languageEnglish
Pages (from-to)2110-2113
Number of pages4
JournalOrganic Letters
Volume18
Issue number9
DOIs
Publication statusPublished - May 6 2016

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antifouling
Structure-Activity Relationship
metathesis
closing
synthesis
analogs
rings

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Total Synthesis of Sarcophytonolide H and Isosarcophytonolide D : Structural Revision of Isosarcophytonolide D and Structure-Antifouling Activity Relationship of Sarcophytonolide H. / Takamura, Hiroyoshi; Kikuchi, Takahiro; Endo, Noriyuki; Fukuda, Yuji; Kadota, Isao.

In: Organic Letters, Vol. 18, No. 9, 06.05.2016, p. 2110-2113.

Research output: Contribution to journalArticle

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