The total synthesis of Hemibrevetoxin B is described. A new cyclization approach, based on the Lewis acid mediated intramolecular cyclization of the γ-oxo-substituted allylic tin having an aldehyde group, produced the 6-6-7-7 polycyclic ether skeleton of the natural product with high stereoselectivity. The 1H and 13C-NMR spectra of synthetic hemibrevetoxin B was identical with those of natural product.
|Number of pages||6|
|Journal||Main Group Metal Chemistry|
|Publication status||Published - Jan 1 1996|
ASJC Scopus subject areas
- Condensed Matter Physics
- Metals and Alloys
- Materials Chemistry