Total synthesis of hemibrevetoxin B via the allylic tin methodology

Isao Kadota, Yoshinori Yamamoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The total synthesis of Hemibrevetoxin B is described. A new cyclization approach, based on the Lewis acid mediated intramolecular cyclization of the γ-oxo-substituted allylic tin having an aldehyde group, produced the 6-6-7-7 polycyclic ether skeleton of the natural product with high stereoselectivity. The 1H and 13C-NMR spectra of synthetic hemibrevetoxin B was identical with those of natural product.

Original languageEnglish
Pages (from-to)361-366
Number of pages6
JournalMain Group Metal Chemistry
Volume19
Issue number6
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Metals and Alloys
  • Materials Chemistry

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