Total synthesis of gambierol

Isao Kadota, Hiroyoshi Takamura, Kumi Sato, Akio Ohno, Kumiko Matsuda, Yoshinori Yamamoto

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

The convergent total synthesis of gambierol (1) is described. The octacyclic ether framework of 1 was constructed via the intramolecular allylation of α-chloroacetoxy ether followed by ring-closing metathesis. A modified Stille coupling was successfully applied to the synthesis of the triene side chain.

Original languageEnglish
Pages (from-to)46-47
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number1
DOIs
Publication statusPublished - Jan 8 2003
Externally publishedYes

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Ether
Ethers
Allylation
gambierol

ASJC Scopus subject areas

  • Chemistry(all)

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Total synthesis of gambierol. / Kadota, Isao; Takamura, Hiroyoshi; Sato, Kumi; Ohno, Akio; Matsuda, Kumiko; Yamamoto, Yoshinori.

In: Journal of the American Chemical Society, Vol. 125, No. 1, 08.01.2003, p. 46-47.

Research output: Contribution to journalArticle

Kadota, I, Takamura, H, Sato, K, Ohno, A, Matsuda, K & Yamamoto, Y 2003, 'Total synthesis of gambierol', Journal of the American Chemical Society, vol. 125, no. 1, pp. 46-47. https://doi.org/10.1021/ja028726d
Kadota, Isao ; Takamura, Hiroyoshi ; Sato, Kumi ; Ohno, Akio ; Matsuda, Kumiko ; Yamamoto, Yoshinori. / Total synthesis of gambierol. In: Journal of the American Chemical Society. 2003 ; Vol. 125, No. 1. pp. 46-47.
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