Total Synthesis of Fontanesine B and Its Isomer: Their Antiproliferative Activity against Human Colorectal Cancer Cells

Takumi Abe, Tomoki Itoh, Masaru Terasaki

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A concise synthesis of pyrano[3,2-e]indole alkaloid fontanesine B by a Fischer indolization is described. This key Fischer indolization starts with the pyran-ring and alkene intact, facilitating potential synthetic applications. Furthermore, fontanesine B and its isomer were evaluated for in vitro antiproliferative activity against human colorectal cancer cells. The isomer of fontanesine B showed higher antiproliferative activity than the natural product, fontanesine B (2).

Original languageEnglish
Article numbere1900116
JournalHelvetica Chimica Acta
Volume102
Issue number7
DOIs
Publication statusPublished - Jul 2019
Externally publishedYes

Keywords

  • alkaloids
  • antiproliferation
  • Fischer
  • indoles
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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