Abstract
A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.
| Original language | English |
|---|---|
| Pages (from-to) | 126-129 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2 2015 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Suizu, H., Shigeoka, D., Aoyama, H., & Yoshimitsu, T. (2015). Total Synthesis of Clavilactone B: A Radical Cyclization-Fragmentation Strategy. Organic Letters, 17(1), 126-129. https://doi.org/10.1021/ol503356m