Abstract
A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.
Original language | English |
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Pages (from-to) | 126-129 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 17 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2 2015 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry