Total Synthesis of Clavilactone B: A Radical Cyclization-Fragmentation Strategy

Hiroshi Suizu, Daisuke Shigeoka, Hiroshi Aoyama, Takehiko Yoshimitsu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.

Original languageEnglish
Pages (from-to)126-129
Number of pages4
JournalOrganic Letters
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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