Abstract
A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.
| Original language | English |
|---|---|
| Pages (from-to) | 126-129 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2 2015 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Cite this
Total Synthesis of Clavilactone B : A Radical Cyclization-Fragmentation Strategy. / Suizu, Hiroshi; Shigeoka, Daisuke; Aoyama, Hiroshi; Yoshimitsu, Takehiko.
In: Organic Letters, Vol. 17, No. 1, 02.01.2015, p. 126-129.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Total Synthesis of Clavilactone B
T2 - A Radical Cyclization-Fragmentation Strategy
AU - Suizu, Hiroshi
AU - Shigeoka, Daisuke
AU - Aoyama, Hiroshi
AU - Yoshimitsu, Takehiko
PY - 2015/1/2
Y1 - 2015/1/2
N2 - A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.
AB - A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization-fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring.
UR - http://www.scopus.com/inward/record.url?scp=84925284812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925284812&partnerID=8YFLogxK
U2 - 10.1021/ol503356m
DO - 10.1021/ol503356m
M3 - Article
C2 - 25513832
AN - SCOPUS:84925284812
VL - 17
SP - 126
EP - 129
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 1
ER -