Abstract
A total synthesis of brevenal is described. The pentacyclic ether core was constructed by the intramolecular allylation of α-acetoxy ether and subsequent ring - closing metathesis. Both of the diene side chains were introduced by Wittig olefination and a Horner - Wadsworth - Emmons reaction, respectively, in a highly stereoselective manner.
Original language | English |
---|---|
Pages (from-to) | 2531-2534 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 11 |
Issue number | 12 |
DOIs | |
Publication status | Published - Jun 18 2009 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry