Total Synthesis of Biselide E, a Marine Polyketide

Ichiro Hayakawa, Kazuaki Suzuki, Masami Okamura, Shota Funakubo, Yuto Onozaki, Dai Kawamura, Takayuki Ohyoshi, Hideo Kigoshi

Research output: Contribution to journalArticle

2 Citations (Scopus)


The total synthesis of biselide E, a marine polyketide isolated from the Okinawan ascidian, has been accomplished. The highlight of this approach is the use of the β-elimination reaction of the chloroacetoxy group for the construction of an unstable six-membered α,β,γ,δ-unsaturated lactone portion at the late stage of the total synthesis.

Original languageEnglish
Pages (from-to)5713-5716
Number of pages4
JournalOrganic Letters
Issue number20
Publication statusPublished - Oct 20 2017

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Hayakawa, I., Suzuki, K., Okamura, M., Funakubo, S., Onozaki, Y., Kawamura, D., Ohyoshi, T., & Kigoshi, H. (2017). Total Synthesis of Biselide E, a Marine Polyketide. Organic Letters, 19(20), 5713-5716.