Total Synthesis of Biselide E, a Marine Polyketide

Ichiro Hayakawa; Kazuaki Suzuki; Masami Okamura; Shota Funakubo; Yuto Onozaki; Dai Kawamura; Takayuki Ohyoshi; Hideo Kigoshi

doi:10.1021/acs.orglett.7b03009

Total Synthesis of Biselide E, a Marine Polyketide

Ichiro Hayakawa, Kazuaki Suzuki, Masami Okamura, Shota Funakubo, Yuto Onozaki, Dai Kawamura, Takayuki Ohyoshi, Hideo Kigoshi

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The total synthesis of biselide E, a marine polyketide isolated from the Okinawan ascidian, has been accomplished. The highlight of this approach is the use of the β-elimination reaction of the chloroacetoxy group for the construction of an unstable six-membered α,β,γ,δ-unsaturated lactone portion at the late stage of the total synthesis.

Original language	English
Pages (from-to)	5713-5716
Number of pages	4
Journal	Organic Letters
Volume	19
Issue number	20
DOIs	https://doi.org/10.1021/acs.orglett.7b03009
Publication status	Published - Oct 20 2017

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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AU - Hayakawa, Ichiro

AU - Suzuki, Kazuaki

AU - Okamura, Masami

AU - Funakubo, Shota

AU - Onozaki, Yuto

AU - Kawamura, Dai

AU - Ohyoshi, Takayuki

AU - Kigoshi, Hideo

PY - 2017/10/20

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