The total synthesis of biselide A based on our earlier strategy of synthesizing haterumalides is reported. The highlights of this approach are the use of regioselective enzymatic hydrolysis for the installation of a C20 oxygen functional group and an asymmetric aldol reaction for the stereoselective introduction of a C3 oxygen functional group.
- asymmetric aldol reaction
- biselide A
- regioselective enzymatic hydrolysis
ASJC Scopus subject areas
- Organic Chemistry