Total synthesis of amphidinolactone A and its absolute configuration

Masahiro Hangyou, Haruaki Ishiyama, Yohei Takahashi, Takaaki Kubota, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Asymmetric synthesis of amphidinolactone A, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp., has been accomplished. Absolute configuration of amphidinolactone A was concluded to be 1 from comparison of the NMR data and [α]D values of synthetic and natural amphidinolactone A.

Original languageEnglish
Pages (from-to)1475-1477
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number13
DOIs
Publication statusPublished - Apr 1 2009
Externally publishedYes

Keywords

  • Amphidinium sp.
  • Amphidinolactone A
  • Macrolide
  • Stereochemistry
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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