Total synthesis of (-)-agelastatin A: An SH2′ radical azidation strategy

Izuru Tsuchimochi, Yuta Kitamura, Hiroshi Aoyama, Shuji Akai, Keiyou Nakai, Takehiko Yoshimitsu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A reagent generated from TMSN3/KMnO4/BnEt3NCl was found to promote an SH2′ radical azidation of a bromo silyl enol ether to furnish an azido silyl enol ether via olefin transposition. With the present azidation protocol, a new synthetic approach to agelastatin A, a potent antitumor marine alkaloid, has been established.

Original languageEnglish
Pages (from-to)9893-9896
Number of pages4
JournalChemical Communications
Volume54
Issue number71
DOIs
Publication statusPublished - Jan 1 2018

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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