Title IgA Nephropathy and Oral Bacterial Species Related to Dental Caries and Periodontitis

Yasuyuki Nagasawa, Taro Misaki, Seigo Ito, Shuhei Naka, Kaoruko Wato, Ryota Nomura, Michiyo Matsumoto-Nakano, Kazuhiko Nakano

Research output: Contribution to journalReview articlepeer-review


A relationship between IgA nephropathy (IgAN) and bacterial infection has been sus-pected. As IgAN is a chronic disease, bacteria that could cause chronic infection in oral areas might be pathogenetic bacteria candidates. Oral bacterial species related to dental caries and periodontitis should be candidates because these bacteria are well known to be pathogenic in chronic dental dis-ease. Recently, several reports have indicated that collagen-binding protein (cnm)-(+) Streptococcs mutans is relate to the incidence of IgAN and the progression of IgAN. Among periodontal bacteria, Treponema denticola, Porphyromonas gingivalis and Campylobacte rectus were found to be related to the incidence of IgAN. These bacteria can cause IgAN-like histological findings in animal models. While the connection between oral bacterial infection, such as infection with S. mutans and periodontal bacteria, and the incidence of IgAN remains unclear, these bacterial infections might cause aber-rantly glycosylated IgA1 in nasopharynx-associated lymphoid tissue, which has been reported to cause IgA deposition in mesangial areas in glomeruli, probably through the alteration of mi-croRNAs related to the expression of glycosylation enzymes. The roles of other factors related to the incidence and progression of IgA, such as genes and cigarette smoking, can also be explained from the perspective of the relationship between these factors and oral bacteria. This review sum-marizes the relationship between IgAN and oral bacteria, such as cnm-(+) S. mutans and periodontal bacteria.

Original languageEnglish
Article number725
JournalInternational journal of molecular sciences
Issue number2
Publication statusPublished - Jan 1 2022


  • Cnm
  • Dental caries
  • IgA nephropathy
  • Infection
  • Mouse
  • Oral bacteria
  • Periodontal bacteria
  • Periodontitis
  • Porphyromonas gingivalis
  • Streptococcus mutans
  • Tonsil

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


Dive into the research topics of 'Title IgA Nephropathy and Oral Bacterial Species Related to Dental Caries and Periodontitis'. Together they form a unique fingerprint.

Cite this