TY - JOUR
T1 - Tissue concentration of intravesically instilled (2″R)-4′-0-tetrahydropyranyl-adriamycin or adriamycin in superficial bladder cancer
AU - Saika, Takashi
AU - Tsushima, Tomoyasu
AU - Nasu, Yasutomo
AU - Noda, Masatoshi
AU - Akebi, Naoki
AU - Kaku, Syunko
AU - Takamatsu, Masatake
AU - Ohmori, Hiroyuki
AU - Uno, Satoru
AU - Johsen, Taiichiro
PY - 1993
Y1 - 1993
N2 - Twenty-one patients with superficial bladder cancer entered an analysis of single dose (2′R)-4′-0-tetrahydropyranyladriamycin (THP) or adriamycin (ADM) administration. The patients in each group that have been or not have been treated previously with anti-cancer drugs were randomized into two groups, one was given THP and the other ADM. Thirty-mg of THP or ADM dissolved in 30 ml of physiologic saline was instilled into the bladder, and retained for 1 hour. After 1 hour retention of the drugs, tumor tissues and normal mucosas were removed by punch biopsy forceps transurethrally. The tissue concentrations of THP and ADM were estimated by high performance liquid chromatography. The tissue concentrations of THP and ADM in the tumors were significantly greater (p<0.05) than those in the normal bladder mucosas. The tissue concentration of THP in the tumors were greater than that of ADM. The tissue concentrations of THP and ADM in the tumor of patients who have been treated with anti-cancer drugs priviously were less than those of patients who have not. This results demonstrated that prior therapy with anti-cancer drug may cause a resistance for intravesical instillation chemotherapy. However in patients with prior therapy, the tissue concentration of THP in the tumors were greater than that of ADM. Based on these findings, THP has been shown to be were effective as an intravesical instillating agent expecially, in cases with prior chemotherapy.
AB - Twenty-one patients with superficial bladder cancer entered an analysis of single dose (2′R)-4′-0-tetrahydropyranyladriamycin (THP) or adriamycin (ADM) administration. The patients in each group that have been or not have been treated previously with anti-cancer drugs were randomized into two groups, one was given THP and the other ADM. Thirty-mg of THP or ADM dissolved in 30 ml of physiologic saline was instilled into the bladder, and retained for 1 hour. After 1 hour retention of the drugs, tumor tissues and normal mucosas were removed by punch biopsy forceps transurethrally. The tissue concentrations of THP and ADM were estimated by high performance liquid chromatography. The tissue concentrations of THP and ADM in the tumors were significantly greater (p<0.05) than those in the normal bladder mucosas. The tissue concentration of THP in the tumors were greater than that of ADM. The tissue concentrations of THP and ADM in the tumor of patients who have been treated with anti-cancer drugs priviously were less than those of patients who have not. This results demonstrated that prior therapy with anti-cancer drug may cause a resistance for intravesical instillation chemotherapy. However in patients with prior therapy, the tissue concentration of THP in the tumors were greater than that of ADM. Based on these findings, THP has been shown to be were effective as an intravesical instillating agent expecially, in cases with prior chemotherapy.
KW - anthracyline derivatives
KW - bladder cancer
KW - intravesical instillation chemotherapy
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U2 - 10.5980/jpnjurol1989.84.1206
DO - 10.5980/jpnjurol1989.84.1206
M3 - Article
C2 - 8355436
AN - SCOPUS:0027163731
VL - 84
SP - 1206
EP - 1210
JO - Japanese Journal of Urology
JF - Japanese Journal of Urology
SN - 0021-5287
IS - 7
ER -