Time-dependent changes in rat hippocampal synapsin I mRNA expression during long-term potentiation

Kiyoshi Morimoto; Keiko Sato; Soichiro Sato; Norihito Yamada; Toshiyuki Hayabara

doi:10.1016/S0006-8993(97)01154-2

Time-dependent changes in rat hippocampal synapsin I mRNA expression during long-term potentiation

Kiyoshi Morimoto, Keiko Sato, Soichiro Sato, Norihito Yamada, Toshiyuki Hayabara

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

We studied the time-dependent changes in synapsin I mRNA levels after hippocampal long-term potentiation (LTP) in rats in vivo. Following LTP induction by stimulating the perforant path, synapsin I mRNA expression in the granule cell layer of the denture gyms ipsilateral to stimulation increased significantly in a time-dependent manner. From 2 to 8 h after stimulation, the synapsin I mRNA levels in the ipsilateral dentate gyms were significantly higher than those of controls subjected to a sham procedure. The synapsin I mRNA level (157.4 ± 7.1% of the control level, mean ± SEM) was at a maximum 8 h after stimulation. The synapsin I mRNA level of animals that received only test pulses did not increase significantly, compared with the control level. These results suggest that the increased level of synapsin I mRNA is related to persistent enhancement of synaptic activity within the neural networks in which dentate granule cells participate in LTP.

Original language	English
Pages (from-to)	57-62
Number of pages	6
Journal	Brain Research
Volume	783
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(97)01154-2
Publication status	Published - Feb 2 1998

Keywords

Dentate gyms
Hippocampus
Long-term potentiation
Synapsin I
mRNA

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Time-dependent changes in rat hippocampal synapsin I mRNA expression during long-term potentiation",

abstract = "We studied the time-dependent changes in synapsin I mRNA levels after hippocampal long-term potentiation (LTP) in rats in vivo. Following LTP induction by stimulating the perforant path, synapsin I mRNA expression in the granule cell layer of the denture gyms ipsilateral to stimulation increased significantly in a time-dependent manner. From 2 to 8 h after stimulation, the synapsin I mRNA levels in the ipsilateral dentate gyms were significantly higher than those of controls subjected to a sham procedure. The synapsin I mRNA level (157.4 ± 7.1% of the control level, mean ± SEM) was at a maximum 8 h after stimulation. The synapsin I mRNA level of animals that received only test pulses did not increase significantly, compared with the control level. These results suggest that the increased level of synapsin I mRNA is related to persistent enhancement of synaptic activity within the neural networks in which dentate granule cells participate in LTP.",

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AU - Morimoto, Kiyoshi

AU - Sato, Keiko

AU - Sato, Soichiro

AU - Yamada, Norihito

AU - Hayabara, Toshiyuki

PY - 1998/2/2

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N2 - We studied the time-dependent changes in synapsin I mRNA levels after hippocampal long-term potentiation (LTP) in rats in vivo. Following LTP induction by stimulating the perforant path, synapsin I mRNA expression in the granule cell layer of the denture gyms ipsilateral to stimulation increased significantly in a time-dependent manner. From 2 to 8 h after stimulation, the synapsin I mRNA levels in the ipsilateral dentate gyms were significantly higher than those of controls subjected to a sham procedure. The synapsin I mRNA level (157.4 ± 7.1% of the control level, mean ± SEM) was at a maximum 8 h after stimulation. The synapsin I mRNA level of animals that received only test pulses did not increase significantly, compared with the control level. These results suggest that the increased level of synapsin I mRNA is related to persistent enhancement of synaptic activity within the neural networks in which dentate granule cells participate in LTP.

AB - We studied the time-dependent changes in synapsin I mRNA levels after hippocampal long-term potentiation (LTP) in rats in vivo. Following LTP induction by stimulating the perforant path, synapsin I mRNA expression in the granule cell layer of the denture gyms ipsilateral to stimulation increased significantly in a time-dependent manner. From 2 to 8 h after stimulation, the synapsin I mRNA levels in the ipsilateral dentate gyms were significantly higher than those of controls subjected to a sham procedure. The synapsin I mRNA level (157.4 ± 7.1% of the control level, mean ± SEM) was at a maximum 8 h after stimulation. The synapsin I mRNA level of animals that received only test pulses did not increase significantly, compared with the control level. These results suggest that the increased level of synapsin I mRNA is related to persistent enhancement of synaptic activity within the neural networks in which dentate granule cells participate in LTP.

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