TY - JOUR
T1 - Time-dependent changes in rat hippocampal synapsin I mRNA expression during long-term potentiation
AU - Morimoto, Kiyoshi
AU - Sato, Keiko
AU - Sato, Soichiro
AU - Yamada, Norihito
AU - Hayabara, Toshiyuki
PY - 1998/2/2
Y1 - 1998/2/2
N2 - We studied the time-dependent changes in synapsin I mRNA levels after hippocampal long-term potentiation (LTP) in rats in vivo. Following LTP induction by stimulating the perforant path, synapsin I mRNA expression in the granule cell layer of the denture gyms ipsilateral to stimulation increased significantly in a time-dependent manner. From 2 to 8 h after stimulation, the synapsin I mRNA levels in the ipsilateral dentate gyms were significantly higher than those of controls subjected to a sham procedure. The synapsin I mRNA level (157.4 ± 7.1% of the control level, mean ± SEM) was at a maximum 8 h after stimulation. The synapsin I mRNA level of animals that received only test pulses did not increase significantly, compared with the control level. These results suggest that the increased level of synapsin I mRNA is related to persistent enhancement of synaptic activity within the neural networks in which dentate granule cells participate in LTP.
AB - We studied the time-dependent changes in synapsin I mRNA levels after hippocampal long-term potentiation (LTP) in rats in vivo. Following LTP induction by stimulating the perforant path, synapsin I mRNA expression in the granule cell layer of the denture gyms ipsilateral to stimulation increased significantly in a time-dependent manner. From 2 to 8 h after stimulation, the synapsin I mRNA levels in the ipsilateral dentate gyms were significantly higher than those of controls subjected to a sham procedure. The synapsin I mRNA level (157.4 ± 7.1% of the control level, mean ± SEM) was at a maximum 8 h after stimulation. The synapsin I mRNA level of animals that received only test pulses did not increase significantly, compared with the control level. These results suggest that the increased level of synapsin I mRNA is related to persistent enhancement of synaptic activity within the neural networks in which dentate granule cells participate in LTP.
KW - Dentate gyms
KW - Hippocampus
KW - Long-term potentiation
KW - Synapsin I
KW - mRNA
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U2 - 10.1016/S0006-8993(97)01154-2
DO - 10.1016/S0006-8993(97)01154-2
M3 - Article
C2 - 9479047
AN - SCOPUS:0031951858
VL - 783
SP - 57
EP - 62
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1
ER -