Time-dependent changes in plasma osteopontin levels in patients with anterior-wall acute myocardial infarction after successful reperfusion: Correlation with left-ventricular volume and function

Chisato Suezawa, Shozo Kusachi, Takashi Murakami, Kenichi Toeda, Satoshi Hirohata, Keigo Nakamura, Keizo Yamamoto, Kazuya Koten, Toru Miyoshi, Yasushi Shiratori

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Abstract

Osteopontin is a secreted extracellular-matrix glycoprotein that plays a role in the healing of remodeling tissue. We examined the relationship of plasma osteopontin levels with left-ventricular (LV) volume and function in 18 consecutive patients who underwent successful reperfusion after anterior-wall acute myocardial infarction (AMI). The plasma osteopontin level was within the control range at admission (mean ± SD 420 ± 195 ng/mL), began to increase on day 2 (935 ± 464 ng/mL), and reached a maximum around day 3 (1139 ± 482 ng/mL). The level remained high on days 4, 5, and 7 (∼1000 ng/mL) and then decreased on day 14. Maximal plasma osteopontin levels and the difference between maximal and minimal levels were positively correlated with LV end-systolic volume index (r =. 58, P

Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalJournal of Laboratory and Clinical Medicine
Volume145
Issue number1
DOIs
Publication statusPublished - Jan 2005

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ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

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