Time Course of Electrocardiographic Changes in Patients with Tako-Tsubo Syndrome - Comparison with Acute Myocardial Infarction with Minimal Enzymatic Release

Satoshi Kurisu, Ichiro Inoue, Takuji Kawagoe, Masaharu Ishihara, Yuji Shimatani, Suji Nakamura, Masashi Yoshida, Naoya Mitsuba, Takaki Hata, Hikaru Sato

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

Background: The time course of the electrocardiographic (ECG) changes in patients with tako-tsubo syndrome remains unknown. Methods and Results: In the present study, 16 patients with tako-tsubo syndrome and 15 patients with anterior acute myocardial infarction with minimal enzymatic release (minimal AMI) were evaluated. Left ventricular dysfunction dramatically resolved approximately 2 weeks later in both groups. In the patients with tako-tsubo syndrome, the admission ECG usually showed ST segment elevation, especially in leads V3-6. T wave inversion deepened progressively to its first negative peak, which occurred at approximately 3 days. The T wave was shallow for several days and then deepened again, the second negative peak occurring at approximately 2-3 weeks. The QT interval was prolonged as the T wave deepened, and shortened as the T wave became shallow. In the patients with minimal AMI, a similar time course of ECG changes was observed after reperfusion. In general, at 3 days or later during the early phase, T wave inversion was deeper and the QTc interval was longer in tako-tsubo syndrome than in minimal AMI, Conclusions: Because the time course of the ECG changes, as well as that of the left ventricular dysfunction, is similar between tako-tsubo syndrome and minimal AMI, these 2 cardiac disorders must be carefully differentiated.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalCirculation Journal
Volume68
Issue number1
DOIs
Publication statusPublished - Jan 1 2004
Externally publishedYes

Keywords

  • Electrocardiography
  • Myocardial contraction
  • Myocardial infarction
  • Tako-tsubo

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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