Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells

Megumi Y. Matsumoto, Hidenori Matsuo, Takashi Oka, Takayasu Fukudome, Kazuhiro Hayashi, Hirokazu Shiraishi, Masakatsu Motomura, Noritoshi Shibuya, Hiroyoshi Ayabe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We investigated immune property of a myoid cell line, established from Fisher rat thymus. Immunization of syngeneic rats with the myoid cells induced anti-rat acetylcholine receptor (AChR). Implantation of them into the thymus failed to induce typical thymic pathology of human myasthenia gravis (MG) or anti-AChR responses. We also demonstrated that the myoid cells were able to present exogenous antigens to T cells and induce antigen-specific T cell proliferation. These results suggest that myoid cells have the potential antigenicity to induce anti-AChR and the functions of antigen-presenting cells, but their expansion in the thymus may not directly cause MG.

Original languageEnglish
Pages (from-to)80-87
Number of pages8
JournalJournal of Neuroimmunology
Volume150
Issue number1-2
DOIs
Publication statusPublished - May 1 2004

    Fingerprint

Keywords

  • Autoantibody
  • Germinal center
  • Myasthenia gravis
  • Myoid cells
  • Thymus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Matsumoto, M. Y., Matsuo, H., Oka, T., Fukudome, T., Hayashi, K., Shiraishi, H., Motomura, M., Shibuya, N., & Ayabe, H. (2004). Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells. Journal of Neuroimmunology, 150(1-2), 80-87. https://doi.org/10.1016/j.jneuroim.2004.01.022