Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells

Megumi Y. Matsumoto, Hidenori Matsuo, Takashi Oka, Takayasu Fukudome, Kazuhiro Hayashi, Hirokazu Shiraishi, Masakatsu Motomura, Noritoshi Shibuya, Hiroyoshi Ayabe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We investigated immune property of a myoid cell line, established from Fisher rat thymus. Immunization of syngeneic rats with the myoid cells induced anti-rat acetylcholine receptor (AChR). Implantation of them into the thymus failed to induce typical thymic pathology of human myasthenia gravis (MG) or anti-AChR responses. We also demonstrated that the myoid cells were able to present exogenous antigens to T cells and induce antigen-specific T cell proliferation. These results suggest that myoid cells have the potential antigenicity to induce anti-AChR and the functions of antigen-presenting cells, but their expansion in the thymus may not directly cause MG.

Original languageEnglish
Pages (from-to)80-87
Number of pages8
JournalJournal of Neuroimmunology
Volume150
Issue number1-2
DOIs
Publication statusPublished - May 2004

Fingerprint

Cholinergic Receptors
Antigen-Presenting Cells
Thymus Gland
Myasthenia Gravis
Antigens
T-Lymphocytes
Immunization
Cell Proliferation
Pathology
Cell Line

Keywords

  • Autoantibody
  • Germinal center
  • Myasthenia gravis
  • Myoid cells
  • Thymus

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Matsumoto, M. Y., Matsuo, H., Oka, T., Fukudome, T., Hayashi, K., Shiraishi, H., ... Ayabe, H. (2004). Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells. Journal of Neuroimmunology, 150(1-2), 80-87. https://doi.org/10.1016/j.jneuroim.2004.01.022

Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells. / Matsumoto, Megumi Y.; Matsuo, Hidenori; Oka, Takashi; Fukudome, Takayasu; Hayashi, Kazuhiro; Shiraishi, Hirokazu; Motomura, Masakatsu; Shibuya, Noritoshi; Ayabe, Hiroyoshi.

In: Journal of Neuroimmunology, Vol. 150, No. 1-2, 05.2004, p. 80-87.

Research output: Contribution to journalArticle

Matsumoto, MY, Matsuo, H, Oka, T, Fukudome, T, Hayashi, K, Shiraishi, H, Motomura, M, Shibuya, N & Ayabe, H 2004, 'Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells', Journal of Neuroimmunology, vol. 150, no. 1-2, pp. 80-87. https://doi.org/10.1016/j.jneuroim.2004.01.022
Matsumoto, Megumi Y. ; Matsuo, Hidenori ; Oka, Takashi ; Fukudome, Takayasu ; Hayashi, Kazuhiro ; Shiraishi, Hirokazu ; Motomura, Masakatsu ; Shibuya, Noritoshi ; Ayabe, Hiroyoshi. / Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells. In: Journal of Neuroimmunology. 2004 ; Vol. 150, No. 1-2. pp. 80-87.
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