Thrombotic Thrombocytopenic Purpura and Myoglobinuric Acute Renal Failure Following Radiation Therapy in a Patient with Polymyositis and Cervical Cancer

Hirofumi Makino, Yoshio Nagake, Kazuhiko Moriwaki, Shuzo Hirakawa, Zensuke Ota, Takaaki Katayama, Hiroyuki Yanai, Kiyoshi Takahashi, Tadaatsu Akagi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

73-year-old woman was admitted to receive radiation treatment for uterine cervical cancer, however a complex series of events ensued, leading to death. She developed an acute exacerbation of polymyositis complicated by thrombotic thrombocytopenic purpura, rhabdomyolysis and acute renal failure. Radiation therapy may have produced an immune disturbance leading to the acute exacerbation of polymyositis. Auto-immune-mediated endothelial damage might have triggered a series of events leading to thrombotic thrombocytopenic purpura. Rhabdomyolysis seemed to be the main cause of acute renal failure. (Internal Medicine 34: 24-27, 1995).

Original languageEnglish
Pages (from-to)24-27
Number of pages4
JournalInternal Medicine
Volume34
Issue number1
DOIs
Publication statusPublished - 1995

Keywords

  • acute tubular necrosis
  • microangiopathic hemolytic anemia
  • myoglobinuria
  • rhabdomyolysis

ASJC Scopus subject areas

  • Internal Medicine

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