Thrombolysis with Low-Dose Tissue Plasminogen Activator 3–4.5 h After Acute Ischemic Stroke in Five Hospital Groups in Japan

Ryuta Morihara; Syoichiro Kono; Kota Sato; Nozomi Hishikawa; Yasuyuki Ohta; Toru Yamashita; Kentaro Deguchi; Yasuhiro Manabe; Yoshiki Takao; Kenichi Kashihara; Satoshi Inoue; Hideki Kiriyama; Koji Abe

doi:10.1007/s12975-016-0448-8

Thrombolysis with Low-Dose Tissue Plasminogen Activator 3–4.5 h After Acute Ischemic Stroke in Five Hospital Groups in Japan

Ryuta Morihara, Syoichiro Kono, Kota Sato, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Kentaro Deguchi, Yasuhiro Manabe, Yoshiki Takao, Kenichi Kashihara, Satoshi Inoue, Hideki Kiriyama, Koji Abe

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

Clinical data from Japan on the safety and real-world outcomes of alteplase (tPA) thrombolysis in the extended therapeutic window are lacking. The aim of this study was to assess the safety and real-world outcomes of tPA administered within 3–4.5 h of stroke onset. The study comprised consecutive acute ischemic stroke patients (n = 177) admitted across five hospitals between September 2012 and August 2014. Patients received intravenous tPA within

Original language	English
Pages (from-to)	111-119
Number of pages	9
Journal	Translational Stroke Research
Volume	7
Issue number	2
DOIs	https://doi.org/10.1007/s12975-016-0448-8
Publication status	Published - Apr 1 2016

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Keywords

Acute stroke
Edaravone
Endovascular treatment
Intracerebral hemorrhage
Recanalization
Tissue-type plasminogen activator

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)
Cardiology and Cardiovascular Medicine

Cite this

Morihara, R., Kono, S., Sato, K., Hishikawa, N., Ohta, Y., Yamashita, T., Deguchi, K., Manabe, Y., Takao, Y., Kashihara, K., Inoue, S., Kiriyama, H., & Abe, K. (2016). Thrombolysis with Low-Dose Tissue Plasminogen Activator 3–4.5 h After Acute Ischemic Stroke in Five Hospital Groups in Japan. Translational Stroke Research, 7(2), 111-119. https://doi.org/10.1007/s12975-016-0448-8

Thrombolysis with Low-Dose Tissue Plasminogen Activator 3–4.5 h After Acute Ischemic Stroke in Five Hospital Groups in Japan. / Morihara, Ryuta; Kono, Syoichiro; Sato, Kota; Hishikawa, Nozomi ; Ohta, Yasuyuki ; Yamashita, Toru; Deguchi, Kentaro; Manabe, Yasuhiro; Takao, Yoshiki; Kashihara, Kenichi; Inoue, Satoshi; Kiriyama, Hideki; Abe, Koji.

In: Translational Stroke Research, Vol. 7, No. 2, 01.04.2016, p. 111-119.

Research output: Contribution to journal › Article

Morihara, R, Kono, S, Sato, K, Hishikawa, N , Ohta, Y , Yamashita, T, Deguchi, K, Manabe, Y, Takao, Y, Kashihara, K, Inoue, S, Kiriyama, H & Abe, K 2016, 'Thrombolysis with Low-Dose Tissue Plasminogen Activator 3–4.5 h After Acute Ischemic Stroke in Five Hospital Groups in Japan', Translational Stroke Research, vol. 7, no. 2, pp. 111-119. https://doi.org/10.1007/s12975-016-0448-8

Morihara, Ryuta ; Kono, Syoichiro ; Sato, Kota ; Hishikawa, Nozomi ; Ohta, Yasuyuki ; Yamashita, Toru ; Deguchi, Kentaro ; Manabe, Yasuhiro ; Takao, Yoshiki ; Kashihara, Kenichi ; Inoue, Satoshi ; Kiriyama, Hideki ; Abe, Koji. / Thrombolysis with Low-Dose Tissue Plasminogen Activator 3–4.5 h After Acute Ischemic Stroke in Five Hospital Groups in Japan. In: Translational Stroke Research. 2016 ; Vol. 7, No. 2. pp. 111-119.

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10.1007/s12975-016-0448-8