Thrombocytosis as a useful prognostic indicator in patients with lung cancer

Keisuke Aoe, Akio Hiraki, Hiroshi Ueoka, Katsuyuki Kiura, Masahiro Tabata, Motoyuki Tanaka, Mitsune Tanimoto

Research output: Contribution to journalArticle

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Abstract

Background: Thrombocytosis can accompany various cancers including lung cancer. This finding has recently been suggested to indicate poor prognosis. Objectives and Methods: We retrospectively examined the clinical records of 611 patients with lung cancer to investigate whether there is a correlation between thrombocytosis, other clinicopathologic factors, and survival Results: Ninety-eight of the patients (16%) manifested thrombocytosis at the time of their first evaluation at our hospital. Thrombocytosis and age (p = 0.0006) and thrombocytosis and performance status (p = 0.0002) are significantly correlated, but thrombocytosis is not related to gender, tumor histology, clinical stage, or serum lactate dehydrogenase concentrations. Survival is significantly shorter in patients with thrombocytosis: [median survival time (MST) 7.5 months; n = 98] than without thrombocytosis (MST 10.1 months; n = 513; p = 0.0029). Multivariate analysis of prognostic factors using the Cox proportional hazards model indicated that thrombocytosis had independent prognostic significance. Conclusion: Thrombocytosis at the first patient evaluation is an independent prognostic factor in lung cancer.

Original languageEnglish
Pages (from-to)170-173
Number of pages4
JournalRespiration
Volume71
Issue number2
DOIs
Publication statusPublished - 2004

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Thrombocytosis
Lung Neoplasms
Survival
L-Lactate Dehydrogenase
Proportional Hazards Models
Histology
Multivariate Analysis

Keywords

  • Lung cancer
  • Multivariate analysis of prognostic factors
  • Platelet count
  • Poor prognosis
  • Thrombocytosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Thrombocytosis as a useful prognostic indicator in patients with lung cancer. / Aoe, Keisuke; Hiraki, Akio; Ueoka, Hiroshi; Kiura, Katsuyuki; Tabata, Masahiro; Tanaka, Motoyuki; Tanimoto, Mitsune.

In: Respiration, Vol. 71, No. 2, 2004, p. 170-173.

Research output: Contribution to journalArticle

Aoe, K, Hiraki, A, Ueoka, H, Kiura, K, Tabata, M, Tanaka, M & Tanimoto, M 2004, 'Thrombocytosis as a useful prognostic indicator in patients with lung cancer', Respiration, vol. 71, no. 2, pp. 170-173. https://doi.org/10.1159/000076679
Aoe, Keisuke ; Hiraki, Akio ; Ueoka, Hiroshi ; Kiura, Katsuyuki ; Tabata, Masahiro ; Tanaka, Motoyuki ; Tanimoto, Mitsune. / Thrombocytosis as a useful prognostic indicator in patients with lung cancer. In: Respiration. 2004 ; Vol. 71, No. 2. pp. 170-173.
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AU - Tanaka, Motoyuki

AU - Tanimoto, Mitsune

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N2 - Background: Thrombocytosis can accompany various cancers including lung cancer. This finding has recently been suggested to indicate poor prognosis. Objectives and Methods: We retrospectively examined the clinical records of 611 patients with lung cancer to investigate whether there is a correlation between thrombocytosis, other clinicopathologic factors, and survival Results: Ninety-eight of the patients (16%) manifested thrombocytosis at the time of their first evaluation at our hospital. Thrombocytosis and age (p = 0.0006) and thrombocytosis and performance status (p = 0.0002) are significantly correlated, but thrombocytosis is not related to gender, tumor histology, clinical stage, or serum lactate dehydrogenase concentrations. Survival is significantly shorter in patients with thrombocytosis: [median survival time (MST) 7.5 months; n = 98] than without thrombocytosis (MST 10.1 months; n = 513; p = 0.0029). Multivariate analysis of prognostic factors using the Cox proportional hazards model indicated that thrombocytosis had independent prognostic significance. Conclusion: Thrombocytosis at the first patient evaluation is an independent prognostic factor in lung cancer.

AB - Background: Thrombocytosis can accompany various cancers including lung cancer. This finding has recently been suggested to indicate poor prognosis. Objectives and Methods: We retrospectively examined the clinical records of 611 patients with lung cancer to investigate whether there is a correlation between thrombocytosis, other clinicopathologic factors, and survival Results: Ninety-eight of the patients (16%) manifested thrombocytosis at the time of their first evaluation at our hospital. Thrombocytosis and age (p = 0.0006) and thrombocytosis and performance status (p = 0.0002) are significantly correlated, but thrombocytosis is not related to gender, tumor histology, clinical stage, or serum lactate dehydrogenase concentrations. Survival is significantly shorter in patients with thrombocytosis: [median survival time (MST) 7.5 months; n = 98] than without thrombocytosis (MST 10.1 months; n = 513; p = 0.0029). Multivariate analysis of prognostic factors using the Cox proportional hazards model indicated that thrombocytosis had independent prognostic significance. Conclusion: Thrombocytosis at the first patient evaluation is an independent prognostic factor in lung cancer.

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