Abstract
Background: Thrombocytosis can accompany various cancers including lung cancer. This finding has recently been suggested to indicate poor prognosis. Objectives and Methods: We retrospectively examined the clinical records of 611 patients with lung cancer to investigate whether there is a correlation between thrombocytosis, other clinicopathologic factors, and survival Results: Ninety-eight of the patients (16%) manifested thrombocytosis at the time of their first evaluation at our hospital. Thrombocytosis and age (p = 0.0006) and thrombocytosis and performance status (p = 0.0002) are significantly correlated, but thrombocytosis is not related to gender, tumor histology, clinical stage, or serum lactate dehydrogenase concentrations. Survival is significantly shorter in patients with thrombocytosis: [median survival time (MST) 7.5 months; n = 98] than without thrombocytosis (MST 10.1 months; n = 513; p = 0.0029). Multivariate analysis of prognostic factors using the Cox proportional hazards model indicated that thrombocytosis had independent prognostic significance. Conclusion: Thrombocytosis at the first patient evaluation is an independent prognostic factor in lung cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 170-173 |
| Number of pages | 4 |
| Journal | Respiration |
| Volume | 71 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2004 |
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Keywords
- Lung cancer
- Multivariate analysis of prognostic factors
- Platelet count
- Poor prognosis
- Thrombocytosis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Physiology
Cite this
Thrombocytosis as a useful prognostic indicator in patients with lung cancer. / Aoe, Keisuke; Hiraki, Akio; Ueoka, Hiroshi; Kiura, Katsuyuki; Tabata, Masahiro; Tanaka, Motoyuki; Tanimoto, Mitsune.
In: Respiration, Vol. 71, No. 2, 2004, p. 170-173.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thrombocytosis as a useful prognostic indicator in patients with lung cancer
AU - Aoe, Keisuke
AU - Hiraki, Akio
AU - Ueoka, Hiroshi
AU - Kiura, Katsuyuki
AU - Tabata, Masahiro
AU - Tanaka, Motoyuki
AU - Tanimoto, Mitsune
PY - 2004
Y1 - 2004
N2 - Background: Thrombocytosis can accompany various cancers including lung cancer. This finding has recently been suggested to indicate poor prognosis. Objectives and Methods: We retrospectively examined the clinical records of 611 patients with lung cancer to investigate whether there is a correlation between thrombocytosis, other clinicopathologic factors, and survival Results: Ninety-eight of the patients (16%) manifested thrombocytosis at the time of their first evaluation at our hospital. Thrombocytosis and age (p = 0.0006) and thrombocytosis and performance status (p = 0.0002) are significantly correlated, but thrombocytosis is not related to gender, tumor histology, clinical stage, or serum lactate dehydrogenase concentrations. Survival is significantly shorter in patients with thrombocytosis: [median survival time (MST) 7.5 months; n = 98] than without thrombocytosis (MST 10.1 months; n = 513; p = 0.0029). Multivariate analysis of prognostic factors using the Cox proportional hazards model indicated that thrombocytosis had independent prognostic significance. Conclusion: Thrombocytosis at the first patient evaluation is an independent prognostic factor in lung cancer.
AB - Background: Thrombocytosis can accompany various cancers including lung cancer. This finding has recently been suggested to indicate poor prognosis. Objectives and Methods: We retrospectively examined the clinical records of 611 patients with lung cancer to investigate whether there is a correlation between thrombocytosis, other clinicopathologic factors, and survival Results: Ninety-eight of the patients (16%) manifested thrombocytosis at the time of their first evaluation at our hospital. Thrombocytosis and age (p = 0.0006) and thrombocytosis and performance status (p = 0.0002) are significantly correlated, but thrombocytosis is not related to gender, tumor histology, clinical stage, or serum lactate dehydrogenase concentrations. Survival is significantly shorter in patients with thrombocytosis: [median survival time (MST) 7.5 months; n = 98] than without thrombocytosis (MST 10.1 months; n = 513; p = 0.0029). Multivariate analysis of prognostic factors using the Cox proportional hazards model indicated that thrombocytosis had independent prognostic significance. Conclusion: Thrombocytosis at the first patient evaluation is an independent prognostic factor in lung cancer.
KW - Lung cancer
KW - Multivariate analysis of prognostic factors
KW - Platelet count
KW - Poor prognosis
KW - Thrombocytosis
UR - http://www.scopus.com/inward/record.url?scp=1942467217&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1942467217&partnerID=8YFLogxK
U2 - 10.1159/000076679
DO - 10.1159/000076679
M3 - Article
C2 - 15031573
AN - SCOPUS:1942467217
VL - 71
SP - 170
EP - 173
JO - Respiration; international review of thoracic diseases
JF - Respiration; international review of thoracic diseases
SN - 0025-7931
IS - 2
ER -