Three serial neurones in the innervation of the colon by the sacral parasympathetic nerve of the dog.

Kiyoko Fukai, H. Fukuda

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Electrophysiological and histological techniques were used to study the nature of the innervation of the colon by the sacral parasympathetic nerve of the dog. Many cells which incorporate horseradish peroxidase (HRP) were observed in ganglia of the pelvic plexus, but not in the sacral cord, after HRP was injected into the wall of the distal colon. Stimulation of the pelvic ganglia by an application of dimethylphenylpiperazinium contracted the distal colon. The contraction was reduced by nicotine applied to the colon. Compound action potentials in responses of rectal strands of the pelvic nerve to stimulation of the sacral ventral roots decreased or disappeared after hexamethonium bromide (C6) was applied to the pelvic plexus. Conduction velocities of the potentials showed that most of the preganglionic fibres were B fibres, and nearly all the post‐ganglionic fibres were C fibres. Many C fibres were observed by electron microscopy in the rectal strands after degeneration of the pelvic and hypogastric nerves. Stimulation of such rectal strands caused a contraction of the colon, which diminished after C6 was applied to the distal colon. These results show that the sacral parasympathetic nerve innervating the colon comprises three serial neurones located in the sacral spinal cord, the pelvic plexus and the myenteric plexus.

Original languageEnglish
Pages (from-to)69-78
Number of pages10
JournalJournal of Physiology
Volume362
Issue number1
DOIs
Publication statusPublished - May 1 1985
Externally publishedYes

Fingerprint

Colon
Dogs
Hypogastric Plexus
Neurons
Spinal Cord
Unmyelinated Nerve Fibers
Horseradish Peroxidase
Ganglia
Dimethylphenylpiperazinium Iodide
Histological Techniques
Myelinated Nerve Fibers
Myenteric Plexus
Hexamethonium
Spinal Nerve Roots
Nicotine
Action Potentials
Electron Microscopy

ASJC Scopus subject areas

  • Physiology

Cite this

Three serial neurones in the innervation of the colon by the sacral parasympathetic nerve of the dog. / Fukai, Kiyoko; Fukuda, H.

In: Journal of Physiology, Vol. 362, No. 1, 01.05.1985, p. 69-78.

Research output: Contribution to journalArticle

@article{d23757b99b1c4bd18e469724b46b7c12,
title = "Three serial neurones in the innervation of the colon by the sacral parasympathetic nerve of the dog.",
abstract = "Electrophysiological and histological techniques were used to study the nature of the innervation of the colon by the sacral parasympathetic nerve of the dog. Many cells which incorporate horseradish peroxidase (HRP) were observed in ganglia of the pelvic plexus, but not in the sacral cord, after HRP was injected into the wall of the distal colon. Stimulation of the pelvic ganglia by an application of dimethylphenylpiperazinium contracted the distal colon. The contraction was reduced by nicotine applied to the colon. Compound action potentials in responses of rectal strands of the pelvic nerve to stimulation of the sacral ventral roots decreased or disappeared after hexamethonium bromide (C6) was applied to the pelvic plexus. Conduction velocities of the potentials showed that most of the preganglionic fibres were B fibres, and nearly all the post‐ganglionic fibres were C fibres. Many C fibres were observed by electron microscopy in the rectal strands after degeneration of the pelvic and hypogastric nerves. Stimulation of such rectal strands caused a contraction of the colon, which diminished after C6 was applied to the distal colon. These results show that the sacral parasympathetic nerve innervating the colon comprises three serial neurones located in the sacral spinal cord, the pelvic plexus and the myenteric plexus.",
author = "Kiyoko Fukai and H. Fukuda",
year = "1985",
month = "5",
day = "1",
doi = "10.1113/jphysiol.1985.sp015663",
language = "English",
volume = "362",
pages = "69--78",
journal = "Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Three serial neurones in the innervation of the colon by the sacral parasympathetic nerve of the dog.

AU - Fukai, Kiyoko

AU - Fukuda, H.

PY - 1985/5/1

Y1 - 1985/5/1

N2 - Electrophysiological and histological techniques were used to study the nature of the innervation of the colon by the sacral parasympathetic nerve of the dog. Many cells which incorporate horseradish peroxidase (HRP) were observed in ganglia of the pelvic plexus, but not in the sacral cord, after HRP was injected into the wall of the distal colon. Stimulation of the pelvic ganglia by an application of dimethylphenylpiperazinium contracted the distal colon. The contraction was reduced by nicotine applied to the colon. Compound action potentials in responses of rectal strands of the pelvic nerve to stimulation of the sacral ventral roots decreased or disappeared after hexamethonium bromide (C6) was applied to the pelvic plexus. Conduction velocities of the potentials showed that most of the preganglionic fibres were B fibres, and nearly all the post‐ganglionic fibres were C fibres. Many C fibres were observed by electron microscopy in the rectal strands after degeneration of the pelvic and hypogastric nerves. Stimulation of such rectal strands caused a contraction of the colon, which diminished after C6 was applied to the distal colon. These results show that the sacral parasympathetic nerve innervating the colon comprises three serial neurones located in the sacral spinal cord, the pelvic plexus and the myenteric plexus.

AB - Electrophysiological and histological techniques were used to study the nature of the innervation of the colon by the sacral parasympathetic nerve of the dog. Many cells which incorporate horseradish peroxidase (HRP) were observed in ganglia of the pelvic plexus, but not in the sacral cord, after HRP was injected into the wall of the distal colon. Stimulation of the pelvic ganglia by an application of dimethylphenylpiperazinium contracted the distal colon. The contraction was reduced by nicotine applied to the colon. Compound action potentials in responses of rectal strands of the pelvic nerve to stimulation of the sacral ventral roots decreased or disappeared after hexamethonium bromide (C6) was applied to the pelvic plexus. Conduction velocities of the potentials showed that most of the preganglionic fibres were B fibres, and nearly all the post‐ganglionic fibres were C fibres. Many C fibres were observed by electron microscopy in the rectal strands after degeneration of the pelvic and hypogastric nerves. Stimulation of such rectal strands caused a contraction of the colon, which diminished after C6 was applied to the distal colon. These results show that the sacral parasympathetic nerve innervating the colon comprises three serial neurones located in the sacral spinal cord, the pelvic plexus and the myenteric plexus.

UR - http://www.scopus.com/inward/record.url?scp=0021894052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021894052&partnerID=8YFLogxK

U2 - 10.1113/jphysiol.1985.sp015663

DO - 10.1113/jphysiol.1985.sp015663

M3 - Article

C2 - 4020695

AN - SCOPUS:0021894052

VL - 362

SP - 69

EP - 78

JO - Journal of Physiology

JF - Journal of Physiology

SN - 0022-3751

IS - 1

ER -