Abstract
Electrophysiological and histological techniques were used to study the nature of the innervation of the colon by the sacral parasympathetic nerve of the dog. Many cells which incorporate horseradish peroxidase (HRP) were observed in ganglia of the pelvic plexus, but not in the sacral cord, after HRP was injected into the wall of the distal colon. Stimulation of the pelvic ganglia by an application of dimethylphenylpiperazinium contracted the distal colon. The contraction was reduced by nicotine applied to the colon. Compound action potentials in responses of rectal strands of the pelvic nerve to stimulation of the sacral ventral roots decreased or disappeared after hexamethonium bromide (C6) was applied to the pelvic plexus. Conduction velocities of the potentials showed that most of the preganglionic fibres were B fibres, and nearly all the post‐ganglionic fibres were C fibres. Many C fibres were observed by electron microscopy in the rectal strands after degeneration of the pelvic and hypogastric nerves. Stimulation of such rectal strands caused a contraction of the colon, which diminished after C6 was applied to the distal colon. These results show that the sacral parasympathetic nerve innervating the colon comprises three serial neurones located in the sacral spinal cord, the pelvic plexus and the myenteric plexus.
| Original language | English |
|---|---|
| Pages (from-to) | 69-78 |
| Number of pages | 10 |
| Journal | Journal of Physiology |
| Volume | 362 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - May 1 1985 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Physiology
Cite this
Three serial neurones in the innervation of the colon by the sacral parasympathetic nerve of the dog. / Fukai, Kiyoko; Fukuda, H.
In: Journal of Physiology, Vol. 362, No. 1, 01.05.1985, p. 69-78.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Three serial neurones in the innervation of the colon by the sacral parasympathetic nerve of the dog.
AU - Fukai, Kiyoko
AU - Fukuda, H.
PY - 1985/5/1
Y1 - 1985/5/1
N2 - Electrophysiological and histological techniques were used to study the nature of the innervation of the colon by the sacral parasympathetic nerve of the dog. Many cells which incorporate horseradish peroxidase (HRP) were observed in ganglia of the pelvic plexus, but not in the sacral cord, after HRP was injected into the wall of the distal colon. Stimulation of the pelvic ganglia by an application of dimethylphenylpiperazinium contracted the distal colon. The contraction was reduced by nicotine applied to the colon. Compound action potentials in responses of rectal strands of the pelvic nerve to stimulation of the sacral ventral roots decreased or disappeared after hexamethonium bromide (C6) was applied to the pelvic plexus. Conduction velocities of the potentials showed that most of the preganglionic fibres were B fibres, and nearly all the post‐ganglionic fibres were C fibres. Many C fibres were observed by electron microscopy in the rectal strands after degeneration of the pelvic and hypogastric nerves. Stimulation of such rectal strands caused a contraction of the colon, which diminished after C6 was applied to the distal colon. These results show that the sacral parasympathetic nerve innervating the colon comprises three serial neurones located in the sacral spinal cord, the pelvic plexus and the myenteric plexus.
AB - Electrophysiological and histological techniques were used to study the nature of the innervation of the colon by the sacral parasympathetic nerve of the dog. Many cells which incorporate horseradish peroxidase (HRP) were observed in ganglia of the pelvic plexus, but not in the sacral cord, after HRP was injected into the wall of the distal colon. Stimulation of the pelvic ganglia by an application of dimethylphenylpiperazinium contracted the distal colon. The contraction was reduced by nicotine applied to the colon. Compound action potentials in responses of rectal strands of the pelvic nerve to stimulation of the sacral ventral roots decreased or disappeared after hexamethonium bromide (C6) was applied to the pelvic plexus. Conduction velocities of the potentials showed that most of the preganglionic fibres were B fibres, and nearly all the post‐ganglionic fibres were C fibres. Many C fibres were observed by electron microscopy in the rectal strands after degeneration of the pelvic and hypogastric nerves. Stimulation of such rectal strands caused a contraction of the colon, which diminished after C6 was applied to the distal colon. These results show that the sacral parasympathetic nerve innervating the colon comprises three serial neurones located in the sacral spinal cord, the pelvic plexus and the myenteric plexus.
UR - http://www.scopus.com/inward/record.url?scp=0021894052&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021894052&partnerID=8YFLogxK
U2 - 10.1113/jphysiol.1985.sp015663
DO - 10.1113/jphysiol.1985.sp015663
M3 - Article
C2 - 4020695
AN - SCOPUS:0021894052
VL - 362
SP - 69
EP - 78
JO - Journal of Physiology
JF - Journal of Physiology
SN - 0022-3751
IS - 1
ER -