Three-dimensional architecture of glomerular extracellular matrices in diabetic glomerulosclerosis

Hirofumi Makino, Shigeaki Nishimura, Toshinori Haramoto, Yasushi Yamasaki, Shuji Ikeda, Zensuke Ota

Research output: Contribution to journalArticle

Abstract

The three-dimensional ultrastructural changes of the glomerular extracellular matrices in diabetic glomerulosclerosis were studied in acellular rat and human diabetic glomeruli by scanning electron microscopy. The mesangial matrix appeared as fenestrated septa with oval stomata between the glomerular capillaries in normal control specimens. In diabetic glomerulosclerosis, both in humans and rats, expansion of mesangial matrix and narrowing of the mesangial fenestrae were observed. A thin layer of the mesangial matrix extended into the peripheral glomerular basement membrane (GBM) subendothelially. Thickening of the GBM in diabetic nephropathy might be due to expansion of the mesangial matrix into the peripheral GBM.

Original languageEnglish
Pages (from-to)124-125
Number of pages2
JournalJournal of Diabetic Complications
Volume5
Issue number2-3
DOIs
Publication statusPublished - Jan 1 1991

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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