The mild reductant chromium(II) chloride can discriminate between alkyl iodides, alkyl radicals, and allylic radicals. In the presence of Cr(II) the alkyl radical is so long-lived that it can undergo intermolecular addition to a 1,3-diene. Rapid one-electron reduction of the formed allylic radical results in an allylic chromium(II) species, which adds to an aldehyde to afford a three-component coupling product.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 1998|
- Radical reactions
- Synthetic methods
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