Three-component coupling based on the "cation pool" method

Seiji Suga; Tomoaki Nishida; Daisuke Yamada; Aiichiro Nagaki; Jun Ichi Yoshida

doi:10.1021/ja0455704

Three-component coupling based on the "cation pool" method

Seiji Suga, Tomoaki Nishida, Daisuke Yamada, Aiichiro Nagaki, Jun Ichi Yoshida

Research output: Contribution to journal › Article › peer-review

94 Citations (Scopus)

Abstract

Sequential one-pot three-component coupling reactions have been developed based on the "cation pool" method. An N-acyliminium ion generated by the "cation pool" method adds to an electron-rich carbon-carbon double bond, such as enamine derivatives and vinyl sulfides, to form the second "cation pool". The addition of nucleophiles such as allylsilanes, enol silyl ethers, Grignard reagents, and organoaluminum compounds led to the formation of the corresponding three-component coupling products.

Original language	English
Pages (from-to)	14338-14339
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	44
DOIs	https://doi.org/10.1021/ja0455704
Publication status	Published - Nov 10 2004
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja0455704

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AU - Suga, Seiji

AU - Nishida, Tomoaki

AU - Yamada, Daisuke

AU - Nagaki, Aiichiro

AU - Yoshida, Jun Ichi

PY - 2004/11/10

Y1 - 2004/11/10

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AB - Sequential one-pot three-component coupling reactions have been developed based on the "cation pool" method. An N-acyliminium ion generated by the "cation pool" method adds to an electron-rich carbon-carbon double bond, such as enamine derivatives and vinyl sulfides, to form the second "cation pool". The addition of nucleophiles such as allylsilanes, enol silyl ethers, Grignard reagents, and organoaluminum compounds led to the formation of the corresponding three-component coupling products.

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Three-component coupling based on the "cation pool" method

Abstract

ASJC Scopus subject areas

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