Thiol modification by bioactivated polyphenols and its potential role in skin Inflammation

Yoshimasa Nakamura; Takeshi Ishii; Naomi Abe; Yoshiyuki Murata

doi:10.1080/09168451.2014.905190

Thiol modification by bioactivated polyphenols and its potential role in skin Inflammation

Yoshimasa Nakamura, Takeshi Ishii, Naomi Abe, Yoshiyuki Murata

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

In the present study, we evaluated the modifying behavior of simple phenolic compounds on the sulfhydryl groups of glutathione and proteins. The catechol-type polyphenols, including protocatechuic acid, but neither the monophenols nor O-methylated catechol, can modify the sulfhydryl groups in a phenol oxidase-dependent manner. The possible involvement of polyphenol bioactivation in the enhancement of skin inflammation was also suggested.

Original language	English
Pages (from-to)	1067-1070
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	78
Issue number	6
DOIs	https://doi.org/10.1080/09168451.2014.905190
Publication status	Published - 2014

Keywords

Glutathione
Polyphenol
Protein thiols
Skin inflammation
Tyrosinase

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

Access to Document

10.1080/09168451.2014.905190

Cite this

@article{84af71f38b1a4867a46ee413e3113f2f,

title = "Thiol modification by bioactivated polyphenols and its potential role in skin Inflammation",

abstract = "In the present study, we evaluated the modifying behavior of simple phenolic compounds on the sulfhydryl groups of glutathione and proteins. The catechol-type polyphenols, including protocatechuic acid, but neither the monophenols nor O-methylated catechol, can modify the sulfhydryl groups in a phenol oxidase-dependent manner. The possible involvement of polyphenol bioactivation in the enhancement of skin inflammation was also suggested.",

keywords = "Glutathione, Polyphenol, Protein thiols, Skin inflammation, Tyrosinase",

author = "Yoshimasa Nakamura and Takeshi Ishii and Naomi Abe and Yoshiyuki Murata",

note = "Funding Information: We thank K. Torikai and H. Ohigashi (Prof. Emer.) at Kyoto University for their technical support. This study was mainly supported by Grant-in-Aid 25292073 (Y.N.) for scientific research from the Ministry of Education, Science, Culture, and Sports of Japan, and in part by Grant-in-Aid for research fellowships from the Japan Society for the Promotion of Science for Young Scientists (N.A.). Publisher Copyright: {\textcopyright} 2014 Japan Society for Bioscience, Biotechnology, and Agrochemistry.",

year = "2014",

doi = "10.1080/09168451.2014.905190",

language = "English",

volume = "78",

pages = "1067--1070",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "6",

}

TY - JOUR

T1 - Thiol modification by bioactivated polyphenols and its potential role in skin Inflammation

AU - Nakamura, Yoshimasa

AU - Ishii, Takeshi

AU - Abe, Naomi

AU - Murata, Yoshiyuki

N1 - Funding Information: We thank K. Torikai and H. Ohigashi (Prof. Emer.) at Kyoto University for their technical support. This study was mainly supported by Grant-in-Aid 25292073 (Y.N.) for scientific research from the Ministry of Education, Science, Culture, and Sports of Japan, and in part by Grant-in-Aid for research fellowships from the Japan Society for the Promotion of Science for Young Scientists (N.A.). Publisher Copyright: © 2014 Japan Society for Bioscience, Biotechnology, and Agrochemistry.

PY - 2014

Y1 - 2014

N2 - In the present study, we evaluated the modifying behavior of simple phenolic compounds on the sulfhydryl groups of glutathione and proteins. The catechol-type polyphenols, including protocatechuic acid, but neither the monophenols nor O-methylated catechol, can modify the sulfhydryl groups in a phenol oxidase-dependent manner. The possible involvement of polyphenol bioactivation in the enhancement of skin inflammation was also suggested.

AB - In the present study, we evaluated the modifying behavior of simple phenolic compounds on the sulfhydryl groups of glutathione and proteins. The catechol-type polyphenols, including protocatechuic acid, but neither the monophenols nor O-methylated catechol, can modify the sulfhydryl groups in a phenol oxidase-dependent manner. The possible involvement of polyphenol bioactivation in the enhancement of skin inflammation was also suggested.

KW - Glutathione

KW - Polyphenol

KW - Protein thiols

KW - Skin inflammation

KW - Tyrosinase

UR - http://www.scopus.com/inward/record.url?scp=84923874135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923874135&partnerID=8YFLogxK

U2 - 10.1080/09168451.2014.905190

DO - 10.1080/09168451.2014.905190

M3 - Article

C2 - 25036136

AN - SCOPUS:84923874135

SN - 0916-8451

VL - 78

SP - 1067

EP - 1070

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 6

ER -

Thiol modification by bioactivated polyphenols and its potential role in skin Inflammation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this