Thermospermine is not a minor polyamine in the plant kingdom

Ayaka Takano, Jun Ichi Kakehi, Taku Takahashi

Research output: Contribution to journalReview article

84 Citations (Scopus)

Abstract

Thermospermine is a structural isomer of spermine, which is one of the polyamines studied extensively in the past, and is produced from spermidine by the action of thermospermine synthase encoded by a gene named ACAULIS5 (ACL5) in plants. According to recent genome sequencing analyses, ACL5-like genes are widely distributed throughout the plant kingdom. In Arabidopsis, ACL5 is expressed specifically during xylem formation from procambial cells to differentiating xylem vessels. Loss-of-function mutants of ACL5 display overproliferation of xylem vessels along with severe dwarfism, suggesting that thermospermine plays a role in the repression of xylem differentiation. Studies of suppressor mutants of acl5 that recover the wild-type phenotype in the absence of thermospermine suggest that thermospermine acts on the translation of specific mRNAs containing upstream open reading frames (uORFs). Thermospermine is a novel type of plant growth regulator and may also serve in the control of wood biomass production.

Original languageEnglish
Pages (from-to)606-616
Number of pages11
JournalPlant and Cell Physiology
Volume53
Issue number4
DOIs
Publication statusPublished - Apr 1 2012

Keywords

  • ACL5
  • Arabidopsis thaliana
  • Polyamine
  • Thermospermine
  • uORF

ASJC Scopus subject areas

  • Physiology
  • Plant Science
  • Cell Biology

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