Thermospermine is not a minor polyamine in the plant kingdom

Ayaka Takano, Jun Ichi Kakehi, Taku Takahashi

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Thermospermine is a structural isomer of spermine, which is one of the polyamines studied extensively in the past, and is produced from spermidine by the action of thermospermine synthase encoded by a gene named ACAULIS5 (ACL5) in plants. According to recent genome sequencing analyses, ACL5-like genes are widely distributed throughout the plant kingdom. In Arabidopsis, ACL5 is expressed specifically during xylem formation from procambial cells to differentiating xylem vessels. Loss-of-function mutants of ACL5 display overproliferation of xylem vessels along with severe dwarfism, suggesting that thermospermine plays a role in the repression of xylem differentiation. Studies of suppressor mutants of acl5 that recover the wild-type phenotype in the absence of thermospermine suggest that thermospermine acts on the translation of specific mRNAs containing upstream open reading frames (uORFs). Thermospermine is a novel type of plant growth regulator and may also serve in the control of wood biomass production.

Original languageEnglish
Pages (from-to)606-616
Number of pages11
JournalPlant and Cell Physiology
Volume53
Issue number4
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Polyamines
xylem vessels
polyamines
xylem
Xylem
mutants
dwarfing
spermine
spermidine
plant growth substances
translation (genetics)
isomers
open reading frames
biomass production
genes
Arabidopsis
phenotype
genome
Dwarfism
Plant Growth Regulators

Keywords

  • ACL5
  • Arabidopsis thaliana
  • Polyamine
  • Thermospermine
  • uORF

ASJC Scopus subject areas

  • Plant Science
  • Physiology
  • Cell Biology

Cite this

Thermospermine is not a minor polyamine in the plant kingdom. / Takano, Ayaka; Kakehi, Jun Ichi; Takahashi, Taku.

In: Plant and Cell Physiology, Vol. 53, No. 4, 04.2012, p. 606-616.

Research output: Contribution to journalArticle

Takano, Ayaka ; Kakehi, Jun Ichi ; Takahashi, Taku. / Thermospermine is not a minor polyamine in the plant kingdom. In: Plant and Cell Physiology. 2012 ; Vol. 53, No. 4. pp. 606-616.
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