Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines.

Jun-Ichi Asaumi, Yuzuru Higuchi, Jun Murakami, Masahiro Kuroda, Koichi Shibuya, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Hiroshi Shigehara, Shoji Kawasaki, Kanji Kishi, Yoshio Hiraki

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Abstract

Thermoradiosensitivity of 8 cell lines of head and neck squamous cell carcinoma (HO-1-u-1, HSC2, HSC3, HSC4, SAS, KB, Hep2, and Ca9-22) was investigated. The differences of radiosensitivity between the cell line with the highest radiosensitivity and the cell line with the lowest radiosensitivity were 1.7-, 7.7-, and 41-fold at 2, 6 and 8 Gy, respectively. The differences between the cell line with the highest thermosensitivity and the cell line with the lowest thermosensitivity were 2.4-, 6.2- and 34.4-fold at 43 degrees C for 40, 60 and 100 min, and 2.6-, 4.9- and 127-fold at 44 degrees C for 20, 30 and 50 min, respectively. These findings indicated that there were large differences in both radiosensitivity and thermosensitivity among the 8 cell lines. There was a negative relationship between radiosensitivity and thermosensitivity (43 degrees C: r=-0.600, 44 degrees C: r=-0.848) in 7 of 8 cell lines, the exception being the HSC4 cell line, which was resistant to both therapies. Four of the 8 cell lines at 43 degrees C and 5 at 44 degrees C in the radiotherapy combined with thermotherapy showed actual survival rates smaller than the theoretical survival rates. Thus, thermoradiotherapy was deemed effective in the head and neck carcinoma cell lines, although 1 of 8 cell lines was resistant to both radiotherapy and thermotherapy.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalInternational Journal of Molecular Medicine
Volume10
Issue number3
Publication statusPublished - Sep 2002

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Cell Line
Radiation Tolerance
Induced Hyperthermia
Carcinoma, squamous cell of head and neck
Radiotherapy
Neck
Head
Carcinoma

ASJC Scopus subject areas

  • Genetics

Cite this

Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines. / Asaumi, Jun-Ichi; Higuchi, Yuzuru; Murakami, Jun; Kuroda, Masahiro; Shibuya, Koichi; Konouchi, Hironobu; Hisatomi, Miki; Matsuzaki, Hidenobu; Shigehara, Hiroshi; Kawasaki, Shoji; Kishi, Kanji; Hiraki, Yoshio.

In: International Journal of Molecular Medicine, Vol. 10, No. 3, 09.2002, p. 287-291.

Research output: Contribution to journalArticle

Asaumi, J-I, Higuchi, Y, Murakami, J, Kuroda, M, Shibuya, K, Konouchi, H, Hisatomi, M, Matsuzaki, H, Shigehara, H, Kawasaki, S, Kishi, K & Hiraki, Y 2002, 'Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines.', International Journal of Molecular Medicine, vol. 10, no. 3, pp. 287-291.
Asaumi, Jun-Ichi ; Higuchi, Yuzuru ; Murakami, Jun ; Kuroda, Masahiro ; Shibuya, Koichi ; Konouchi, Hironobu ; Hisatomi, Miki ; Matsuzaki, Hidenobu ; Shigehara, Hiroshi ; Kawasaki, Shoji ; Kishi, Kanji ; Hiraki, Yoshio. / Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines. In: International Journal of Molecular Medicine. 2002 ; Vol. 10, No. 3. pp. 287-291.
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abstract = "Thermoradiosensitivity of 8 cell lines of head and neck squamous cell carcinoma (HO-1-u-1, HSC2, HSC3, HSC4, SAS, KB, Hep2, and Ca9-22) was investigated. The differences of radiosensitivity between the cell line with the highest radiosensitivity and the cell line with the lowest radiosensitivity were 1.7-, 7.7-, and 41-fold at 2, 6 and 8 Gy, respectively. The differences between the cell line with the highest thermosensitivity and the cell line with the lowest thermosensitivity were 2.4-, 6.2- and 34.4-fold at 43 degrees C for 40, 60 and 100 min, and 2.6-, 4.9- and 127-fold at 44 degrees C for 20, 30 and 50 min, respectively. These findings indicated that there were large differences in both radiosensitivity and thermosensitivity among the 8 cell lines. There was a negative relationship between radiosensitivity and thermosensitivity (43 degrees C: r=-0.600, 44 degrees C: r=-0.848) in 7 of 8 cell lines, the exception being the HSC4 cell line, which was resistant to both therapies. Four of the 8 cell lines at 43 degrees C and 5 at 44 degrees C in the radiotherapy combined with thermotherapy showed actual survival rates smaller than the theoretical survival rates. Thus, thermoradiotherapy was deemed effective in the head and neck carcinoma cell lines, although 1 of 8 cell lines was resistant to both radiotherapy and thermotherapy.",
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