Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines.

Jun Ichi Asaumi, Yuzuru Higuchi, Jun Murakami, Masahiro Kuroda, Koichi Shibuya, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Hiroshi Shigehara, Shoji Kawasaki, Kanji Kishi, Yoshio Hiraki

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6 Citations (Scopus)


Thermoradiosensitivity of 8 cell lines of head and neck squamous cell carcinoma (HO-1-u-1, HSC2, HSC3, HSC4, SAS, KB, Hep2, and Ca9-22) was investigated. The differences of radiosensitivity between the cell line with the highest radiosensitivity and the cell line with the lowest radiosensitivity were 1.7-, 7.7-, and 41-fold at 2, 6 and 8 Gy, respectively. The differences between the cell line with the highest thermosensitivity and the cell line with the lowest thermosensitivity were 2.4-, 6.2- and 34.4-fold at 43 degrees C for 40, 60 and 100 min, and 2.6-, 4.9- and 127-fold at 44 degrees C for 20, 30 and 50 min, respectively. These findings indicated that there were large differences in both radiosensitivity and thermosensitivity among the 8 cell lines. There was a negative relationship between radiosensitivity and thermosensitivity (43 degrees C: r=-0.600, 44 degrees C: r=-0.848) in 7 of 8 cell lines, the exception being the HSC4 cell line, which was resistant to both therapies. Four of the 8 cell lines at 43 degrees C and 5 at 44 degrees C in the radiotherapy combined with thermotherapy showed actual survival rates smaller than the theoretical survival rates. Thus, thermoradiotherapy was deemed effective in the head and neck carcinoma cell lines, although 1 of 8 cell lines was resistant to both radiotherapy and thermotherapy.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalInternational journal of molecular medicine
Issue number3
Publication statusPublished - Sep 2002

ASJC Scopus subject areas

  • Genetics


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