Thermoradiotherapy combined with adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines

Yuzuru Higuchi, Jun Ichi Asaumi, J. U.N. Murakami, Hidenobu Matsuzaki, Toru Wakasa, Tetsuyoshi Inoue, Hironobu Konoucni, Miki Hisatomi, Yoshinobu Yanagi, Yasutoshi Honda, Hiroshi Shigehara, Kanji Kishi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We examined effects of recombinant p53-expressing adenovirus combined with thermoradiotherapy in 8 head and neck squamous cell carcinoma (SCC) cell lines to improve the outcomes of the threatment of advanced head and neck cancer. The p53 gene therapy did not improve the discrepancy between thermoradiosensitivities among the 8 SCC cell lines. However, p53 gene therapy improved the effects of thermoradiotherapy in all 8 cell lines, and there were significant differences in four situations of the HSC4 44°C (p=0.032), SAS at 44°C (p=0.029), the KB at 43°C (p=0.025), and the Ca9-22 43°C (p=0.020). In comparing the survival rates of thermoradiotherapy with those of thermotherapy and radiotherapy, thermoradiotherapy demonstrated actual survival rates less than theoretical survival rates based on the survival rates of thermotherapy multiplied by the survival rates of radiotherapy in almost all treatments of thermoradio-gene therapy of the 8 SCC cell lines. These results demonstrate that thermoradiotherapy combined with p53 gene therapy may be a useful tool in treating SCC cells.

Original languageEnglish
Pages (from-to)415-420
Number of pages6
JournalOncology reports
Volume10
Issue number2
DOIs
Publication statusPublished - Mar 2003

Keywords

  • Conservative combined therapy
  • Gene therapy
  • Radiotherapy
  • Thermotherapy
  • p53

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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